Sharelle A Sturgeon
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Explore the profile of Sharelle A Sturgeon including associated specialties, affiliations and a list of published articles.
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13
Citations
421
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Recent Articles
1.
Maclean J, Tomkins A, Sturgeon S, Hofma B, Alwis I, Samson A, et al.
Blood Adv
. 2022 Jun;
6(18):5449-5462.
PMID: 35767737
Recanalization with restored cerebral perfusion is the primary goal of thrombolytic therapy in acute ischemic stroke. The identification of adjunctive therapies that can be safely used to enhance thrombolysis in...
2.
Lee N, Selan C, Chia J, Sturgeon S, Wright D, Zamani A, et al.
Sci Rep
. 2020 Oct;
10(1):18170.
PMID: 33097782
Stroke is caused by obstructed blood flow (ischaemia) or unrestricted bleeding in the brain (haemorrhage). Global brain ischaemia occurs after restricted cerebral blood flow e.g. during cardiac arrest. Following ischaemic...
3.
Sashindranath M, Sturgeon S, French S, Craenmehr D, Selan C, Freddi S, et al.
Res Pract Thromb Haemost
. 2019 Apr;
3(2):197-206.
PMID: 31011704
Background: Arterial thrombosis models are important for preclinical evaluation of antithrombotics but how anesthetic protocol can influence experimental results is not studied. Objectives: We studied how three most commonly used...
4.
Samson A, Ju L, Kim H, Zhang S, Lee J, Sturgeon S, et al.
Sci Rep
. 2015 Nov;
5:16171.
PMID: 26530459
The Open Field (OF) test is one of the most commonly used assays for assessing exploratory behaviour and generalised locomotor activity in rodents. Nevertheless, the vast majority of researchers still...
5.
Lee H, Sturgeon S, Jackson S, Hamilton J
Thromb Haemost
. 2011 Dec;
107(2):328-37.
PMID: 22187047
Developing novel anti-platelet therapies is an important clinical strategy for the prevention of arterial thromboses which cause heart attacks and most strokes. Thrombin activates platelets via protease-activated receptors (PARs), and...
6.
Liu Y, Gao X, Fang L, Jennings N, Su Y, Q X, et al.
Arterioscler Thromb Vasc Biol
. 2011 Jan;
31(4):834-41.
PMID: 21252067
Objective: The goal of this study was to investigate the role of platelets in systemic and cardiac inflammatory responses and the development of postinfarct ventricular complications, as well as the...
7.
Sturgeon S, Jones C, Angus J, Wright C
Eur J Pharmacol
. 2008 May;
587(1-3):209-15.
PMID: 18455722
Phosphoinositide 3-kinase (PI3K) beta has been shown to play a critical role in shear-induced arterial thrombosis. The anti-thrombotic effects of a beta isoform selective PI3K inhibitor, TGX221, were compared to...
8.
Daykin H, Sturgeon S, Jones C, Wright C
Thromb Res
. 2006 Jan;
118(6):755-62.
PMID: 16410020
Introduction: Many antithrombotic drugs may have a deleterious effect on normal haemostasis leading to bleeding complications. The aim of this study was to determine if sub-therapeutic (low) doses of antithrombotic...
9.
Mangin P, Yap C, Nonne C, Sturgeon S, Goncalves I, Yuan Y, et al.
Blood
. 2006 Jan;
107(11):4346-53.
PMID: 16391010
Fibrillar collagens are among the most potent activators of platelets and play an important role in the initiation of thrombosis. The glycoprotein VI (GPVI)/FcRgamma-chain complex is a central collagen receptor...
10.
Sturgeon S, Jones C, Angus J, Wright C
J Pharmacol Toxicol Methods
. 2005 Aug;
53(1):20-9.
PMID: 16087355
Introduction: Animal preparations of arterial thrombosis play a crucial role in the discovery and validation of novel drug targets in vivo, aiding in the selection of new drugs for clinical...