Andre L Samson
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Explore the profile of Andre L Samson including associated specialties, affiliations and a list of published articles.
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45
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1552
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Recent Articles
1.
Longley R, Samson A, Atkin-Smith G, Carey Hulyer A, Ashton T, Davidson N
Immunol Cell Biol
. 2025 Feb;
103(3):251-255.
PMID: 39957558
In this article, we discuss our experiences and perspectives in forming a workplace Parents Group. We reflect on the need for these networks, what has worked well, and the challenges...
2.
Hoblos H, Cawthorne W, Samson A, Murphy J
Trends Biochem Sci
. 2024 Dec;
50(2):92-105.
PMID: 39730228
Necroptosis is a mode of programmed cell death executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following its activation by the upstream receptor-interacting protein kinase-3 (RIPK3), subsequent to activation...
3.
MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions
Chiou S, Cawthorne W, Soerianto T, Hofferek V, Patel K, Garnish S, et al.
Cell Death Dis
. 2024 Nov;
15(11):851.
PMID: 39572538
Mixed lineage kinase domain-like (MLKL) is a pseudokinase, best known for its role as the terminal effector of the necroptotic cell death pathway. MLKL-mediated necroptosis has long been linked to...
4.
Tye H, Conos S, Djajawi T, Gottschalk T, Abdoulkader N, Kong I, et al.
Life Sci Alliance
. 2024 Nov;
8(1).
PMID: 39532538
Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction-associated fatty liver disease (MAFLD). However, the exact contribution of core cell death machinery to disease manifestations remains ill-defined....
5.
Atkin-Smith G, Santavanond J, Light A, Rimes J, Samson A, Er J, et al.
Nat Commun
. 2024 Oct;
15(1):8802.
PMID: 39438460
Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly exposed to a variety of molecular factors and...
6.
Samson A, Murphy J
Cell Death Differ
. 2024 Jun;
31(7):833-835.
PMID: 38834666
No abstract available.
7.
Chiou S, Al-Ani A, Pan Y, Patel K, Kong I, Whitehead L, et al.
EMBO Mol Med
. 2024 May;
16(7):1717-1749.
PMID: 38750308
Necroptosis is a lytic form of regulated cell death reported to contribute to inflammatory diseases of the gut, skin and lung, as well as ischemic-reperfusion injuries of the kidney, heart...
8.
Garnish S, Martin K, Kauppi M, Jackson V, Ambrose R, Eng V, et al.
Nat Commun
. 2023 Sep;
14(1):6046.
PMID: 37770424
Across the globe, 2-3% of humans carry the p.Ser132Pro single nucleotide polymorphism in MLKL, the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. Here we show...
9.
Vucur M, Ghallab A, Schneider A, Adili A, Cheng M, Castoldi M, et al.
Immunity
. 2023 Jun;
56(7):1578-1595.e8.
PMID: 37329888
It is currently not well known how necroptosis and necroptosis responses manifest in vivo. Here, we uncovered a molecular switch facilitating reprogramming between two alternative modes of necroptosis signaling in...
10.
Tovey Crutchfield E, Garnish S, Day J, Anderton H, Chiou S, Hempel A, et al.
Cell Death Differ
. 2023 Feb;
30(4):1059-1071.
PMID: 36755069
MLKL and RIPK3 are the core signaling proteins of the inflammatory cell death pathway, necroptosis, which is a known mediator and modifier of human disease. Necroptosis has been implicated in...