James A Angus
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Explore the profile of James A Angus including associated specialties, affiliations and a list of published articles.
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53
Citations
726
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Recent Articles
1.
Betrie A, Abdul-Ridha A, Hartono H, Chalmers D, Wright C, Scott D, et al.
Biochem Pharmacol
. 2024 Feb;
222:116092.
PMID: 38408679
Clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) is an antimicrobial agent whose actions as a zinc or copper ionophore and an iron chelator revived the interest in similar compounds for the treatment of fungal and...
2.
Mazeh A, Angus J, Wright C
Eur J Pharmacol
. 2021 Aug;
909:174433.
PMID: 34416240
Cannabidiol is increasingly considered for treatment of a wide range of medical conditions. Binding studies suggest that cannabidiol binds to CB receptors. In the rat isolated vas deferens bioassay, a...
3.
Betrie A, Brock J, Harraz O, Bush A, He G, Nelson M, et al.
Nat Commun
. 2021 Jun;
12(1):3296.
PMID: 34075043
Zinc, an abundant transition metal, serves as a signalling molecule in several biological systems. Zinc transporters are genetically associated with cardiovascular diseases but the function of zinc in vascular tone...
4.
Mazeh A, Angus J, Wright C
Eur J Pharmacol
. 2020 Dec;
891:173767.
PMID: 33275960
The pharmacology of cannabidiol, the non-psychoactive major component of Cannabis sativa, is of growing interest as it becomes more widely prescribed. This study aimed to examine the effects of cannabidiol...
5.
Khammy M, Truong C, Wright C, Angus J
Eur J Pharmacol
. 2020 Jun;
882:173304.
PMID: 32592771
Recently, the β-adrenoceptor agonist terbutaline was shown to have α-adrenolytic activity in mouse isolated pulmonary arteries in vitro and to lower pulmonary artery pressure in anaesthetised mice. The aim of...
6.
Khammy M, Angus J, Wright C
Heliyon
. 2020 May;
6(4):e03810.
PMID: 32368652
Objectives: The vascular amplifier in hypertension is a result of structural changes in resistance arteries. We estimated the vascular amplifier hypertensive:normotensive (H:N) ratio in the renal bed compared with the...
7.
Mazeh A, Angus J, Wright C
Auton Neurosci
. 2019 Nov;
222:102588.
PMID: 31669796
The vas deferens responds to a single electrical pulse with a biphasic contraction caused by cotransmitters ATP and noradrenaline. Removing Mg (normally 1.2 mM) from the physiological salt solution (PSS)...
8.
Angus J, Wright C
Eur J Pharmacol
. 2019 May;
855:124-136.
PMID: 31063771
In the pulmonary vasculature there is clearance of endothelin-1 from the circulation mediated by endothelin ET receptors. This study explored the haemodynamic effects of endothelin-1 and its clearance in the...
9.
10.
Angus J, Hughes R, Wright C
Pharmacol Res Perspect
. 2017 Dec;
5(6).
PMID: 29226623
Dual endothelin ET and ET receptor antagonists are approved therapy for pulmonary artery hypertension (PAH). We hypothesized that ET receptor-mediated clearance of endothelin-1 at specific vascular sites may compromise this...