Shamith A Samarajiwa
Overview
Explore the profile of Shamith A Samarajiwa including associated specialties, affiliations and a list of published articles.
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18
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1510
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Recent Articles
1.
Newsham I, Sendera M, Jammula S, Samarajiwa S
Biol Methods Protoc
. 2024 Jun;
9(1):bpae028.
PMID: 38903861
Cancer, a collection of more than two hundred different diseases, remains a leading cause of morbidity and mortality worldwide. Usually detected at the advanced stages of disease, metastatic cancer accounts...
2.
Tomimatsu K, Bihary D, Olan I, Parry A, Schoenfelder S, Chan A, et al.
Nat Aging
. 2023 Apr;
2(1):31-45.
PMID: 37118356
Senescence is a fate-determined state, accompanied by reorganization of heterochromatin. Although lineage-appropriate genes can be temporarily repressed through facultative heterochromatin, stable silencing of lineage-inappropriate genes often involves the constitutive heterochromatic...
3.
Rossi S, Newsham I, Pita S, Brennan K, Park G, Smith C, et al.
Sci Adv
. 2022 Sep;
8(39):eabn9828.
PMID: 36170366
Current gold standard diagnostic strategies are unable to accurately differentiate malignant from benign small renal masses preoperatively; consequently, 20% of patients undergo unnecessary surgery. Devising a more confident presurgical diagnosis...
4.
Patel S, Hirosue S, Rodrigues P, Vojtasova E, Richardson E, Ge J, et al.
Nature
. 2022 Jun;
606(7916):999-1006.
PMID: 35676472
Large-scale human genetic data have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analyses of patient samples,...
5.
Gong C, Krupka J, Gao J, Grigoropoulos N, Giotopoulos G, Asby R, et al.
Mol Cell
. 2021 Aug;
81(19):4059-4075.e11.
PMID: 34437837
DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown. Here,...
6.
Gao J, Sidiropoulou E, Walker I, Krupka J, Mizielinski K, Usheva Z, et al.
Blood
. 2021 May;
138(11):959-964.
PMID: 33988691
Serum and glucocorticoid-regulated kinase 1 (SGK1) is one of the most frequently mutated genes in diffuse large B-cell lymphoma (DLBCL). However, little is known about its function or the consequence...
7.
Olan I, Parry A, Schoenfelder S, Narita M, Ito Y, Chan A, et al.
Nat Commun
. 2020 Nov;
11(1):6049.
PMID: 33247104
Senescence is a state of stable proliferative arrest, generally accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-promoter interactions, facilitated by chromatin loops, play a key role in...
8.
Syafruddin S, Rodrigues P, Vojtasova E, Patel S, Zaini M, Burge J, et al.
Nat Commun
. 2019 Mar;
10(1):1152.
PMID: 30858363
Transcriptional networks are critical for the establishment of tissue-specific cellular states in health and disease, including cancer. Yet, the transcriptional circuits that control carcinogenesis remain poorly understood. Here we report...
9.
Rodrigues P, Patel S, Harewood L, Olan I, Vojtasova E, Syafruddin S, et al.
Cancer Discov
. 2018 Jun;
8(7):850-865.
PMID: 29875134
Metastases, the spread of cancer cells to distant organs, cause the majority of cancer-related deaths. Few metastasis-specific driver mutations have been identified, suggesting aberrant gene regulation as a source of...
10.
Parry A, Hoare M, Bihary D, Hansel-Hertsch R, Smith S, Tomimatsu K, et al.
Nat Commun
. 2018 May;
9(1):1840.
PMID: 29743479
Senescent cells interact with the surrounding microenvironment achieving diverse functional outcomes. We have recently identified that NOTCH1 can drive 'lateral induction' of a unique senescence phenotype in adjacent cells by...