Saroor A Patel
Overview
Explore the profile of Saroor A Patel including associated specialties, affiliations and a list of published articles.
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7
Citations
152
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Recent Articles
1.
Wesolowski L, Ge J, Castillon L, Sesia D, Dyas A, Hirosue S, et al.
iScience
. 2023 Aug;
26(8):107360.
PMID: 37554444
Lineage switching can induce therapy resistance in cancer. Yet, how lineage fidelity is maintained and how it can be lost remain poorly understood. Here, we have used CRISPR-Cas9-based genetic screening...
2.
Patel S, Hirosue S, Rodrigues P, Vojtasova E, Richardson E, Ge J, et al.
Nature
. 2022 Jun;
606(7916):999-1006.
PMID: 35676472
Large-scale human genetic data have shown that cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analyses of patient samples,...
3.
Patel S, Rodrigues P, Wesolowski L, Vanharanta S
Br J Cancer
. 2020 Nov;
124(1):3-12.
PMID: 33144692
Metastasis remains the leading cause of cancer-associated mortality, and a detailed understanding of the metastatic process could suggest new therapeutic avenues. However, how metastatic phenotypes arise at the genomic level...
4.
Syafruddin S, Rodrigues P, Vojtasova E, Patel S, Zaini M, Burge J, et al.
Nat Commun
. 2019 Mar;
10(1):1152.
PMID: 30858363
Transcriptional networks are critical for the establishment of tissue-specific cellular states in health and disease, including cancer. Yet, the transcriptional circuits that control carcinogenesis remain poorly understood. Here we report...
5.
Zaini M, Patel S, Syafruddin S, Rodrigues P, Vanharanta S
Sci Rep
. 2018 Aug;
8(1):12063.
PMID: 30104738
Tissue-specific transcriptional programs control most biological phenotypes, including disease states such as cancer. However, the molecular details underlying transcriptional specificity is largely unknown, hindering the development of therapeutic approaches. Here,...
6.
Rodrigues P, Patel S, Harewood L, Olan I, Vojtasova E, Syafruddin S, et al.
Cancer Discov
. 2018 Jun;
8(7):850-865.
PMID: 29875134
Metastases, the spread of cancer cells to distant organs, cause the majority of cancer-related deaths. Few metastasis-specific driver mutations have been identified, suggesting aberrant gene regulation as a source of...
7.
Patel S, Vanharanta S
Mol Oncol
. 2016 Oct;
11(1):79-96.
PMID: 27756687
Genetic analyses of cancer progression in patient samples and model systems have thus far failed to identify specific mutational drivers of metastasis. Yet, at least in experimental systems, metastatic cancer...