Sergio E Alvarez
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Explore the profile of Sergio E Alvarez including associated specialties, affiliations and a list of published articles.
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1147
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Recent Articles
1.
Vettorazzi M, Diaz I, Angelina E, Salido S, Gutierrez L, Alvarez S, et al.
Bioorg Chem
. 2024 Jan;
144:107112.
PMID: 38237390
We report here the virtual screening design, synthesis and activity of eight new inhibitors of SphK1. For this study we used a pre-trained Graph Convolutional Network (GCN) combined with docking...
2.
Perez C, Falcon C, Mons J, Orlandi F, Sangiacomo M, Fernandez-Munoz J, et al.
Biochim Biophys Acta Mol Basis Dis
. 2023 Jul;
1869(7):166801.
PMID: 37419396
Over the last years, the incidence of melanoma, the deadliest form of skin cancer, has risen significantly. Nearly half of the melanoma patients exhibit the BRAF mutation. Although the use...
3.
Blanco H, Perez C, Banchio C, Alvarez S, Ciuffo G
Heliyon
. 2023 May;
9(5):e15656.
PMID: 37144208
Neuroblastoma, the most common extracranial solid tumor occurring in childhood, originates from the aberrant proliferation of neural crest cells. Accordingly, the mechanism underling neuronal differentiation could provide new strategies for...
4.
Rodriguez Y, Campos L, Castro M, Bannoud N, Blidner A, Filippa V, et al.
Cells
. 2020 Nov;
9(11).
PMID: 33202705
The role of tumor necrosis factor-α (TNF-α) in shaping the tumor microenvironment is ambiguous. Consistent with its uncertain role in melanoma, TNF-α plays a dual role, either acting as a...
5.
Campos L, Garibotto F, Angelina E, Kos J, Gonec T, Marvanova P, et al.
Bioorg Chem
. 2020 Aug;
103:104145.
PMID: 32801082
The oncogenic mutated kinase BRAF is an attractive molecular target because it is expressed in several human cancers, including melanoma. To present, only three BRAF small inhibitors are approved by...
6.
Campos L, Garibotto F, Angelina E, Kos J, Tomasic T, Zidar N, et al.
Bioorg Chem
. 2019 Aug;
91:103125.
PMID: 31401373
The identification of the V600E activating mutation in the protein kinase BRAF in around 50% of melanoma patients has driven the development of highly potent small inhibitors (BRAFi) of the...
7.
Castro M, Campos L, Rodriguez Y, Alvarez S
Methods Mol Biol
. 2017 Jul;
1697:117-131.
PMID: 28755279
Sphingosine-1-phosphate (S1P) is a bioactive lipid that modulates migratory behavior of cells during embryonic development. In addition, S1P might promote tumor progression by enhancing migratory ability and invasiveness of tumor...
8.
Rodriguez Y, Campos L, Castro M, Aladhami A, Oskeritzian C, Alvarez S
Front Oncol
. 2016 Nov;
6:218.
PMID: 27800303
In the last 15 years, increasing evidences demonstrate a strong link between sphingosine-1-phosphate (S1P) and both normal physiology and progression of different diseases, including cancer and inflammation. Indeed, numerous studies...
9.
Campos L, Rodriguez Y, Leopoldino A, Hait N, Lopez Bergami P, Castro M, et al.
Mol Cell Biol
. 2015 Nov;
36(2):320-9.
PMID: 26552704
Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that regulates many processes in inflammation and cancer. S1P is a ligand for five G-protein-coupled receptors, S1PR1 to -5, and also has important...
10.
Price M, Oskeritzian C, Falanga Y, Harikumar K, Allegood J, Alvarez S, et al.
J Allergy Clin Immunol
. 2012 Sep;
131(2):501-11.e1.
PMID: 22939756
Background: Sphingosine-1-phosphate (S1P), which is produced by 2 sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2, has been implicated in IgE-mediated mast cell responses. However, studies of allergic inflammation in isotype-specific...