Sergey N Krylov
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Explore the profile of Sergey N Krylov including associated specialties, affiliations and a list of published articles.
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162
Citations
1380
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Recent Articles
1.
Wang T, Latimer J, Rukundo J, Kogan I, Krylova S, Schreiber S, et al.
Precis Chem
. 2025 Feb;
3(2):89-104.
PMID: 40018450
Equilibrium constants are essential for understanding and predicting the behavior of chemical systems across various scientific disciplines. Traditionally, these constants are computed via nonlinear regression of reaction isotherms, which show...
2.
Che X, Ivanov N, Krylova S, Krylov S
Anal Chem
. 2025 Feb;
97(7):3920-3925.
PMID: 39937443
Electrophoretically facilitated layer-by-layer assembly of gold nanoparticles (GNPs) in lateral flow immunoassays (LFIAs) significantly enhances the signal-to-background ratio and, consequently, the diagnostic sensitivity of these tests. However, conventional two-reservoir electrophoresis...
3.
Le A, Teclemichael E, Krylova S, Krylov S
JACS Au
. 2024 Dec;
4(12):4910-4920.
PMID: 39735910
Maintaining stringent conditions in SELEX (Systematic Evolution of Ligands by EXponential enrichment) is crucial for obtaining high-affinity aptamers. However, excessive stringency greatly increases the risk of SELEX failure. Controlling stringency...
4.
Haghayegh F, Haghani E, Norouziazad A, Ghavamabadi H, Aggarwal S, Orszulik R, et al.
Biosens Bioelectron
. 2024 Dec;
271:117079.
PMID: 39721464
Rapid, point-of-care tests are critical for early diagnosis of disease and detection of biological threats. Lateral flow immunoassays (LFIAs) are well-suited for point-of-care testing due to their ease of use...
5.
Wang T, Rukundo J, Mao Z, Krylov S
ACS Chem Biol
. 2024 Aug;
19(9):1852-1867.
PMID: 39121869
The equilibrium dissociation constant () is a major characteristic of affinity complexes and one of the most frequently determined physicochemical parameters. Despite its significance, the values of obtained for the...
6.
7.
Kohlmann P, Krylov S, Marchand P, Jose J
Pharmaceuticals (Basel)
. 2024 Apr;
17(4).
PMID: 38675476
Heat shock protein 90 (HSP90) is a critical target for anticancer and anti-fungal-infection therapies due to its central role as a molecular chaperone involved in protein folding and activation. In...
8.
Ivanov N, Panferov V, Krylov S
Anal Chem
. 2024 Feb;
PMID: 38324657
Nonsteady-state behaviors are not expected in electric circuits that lack significant capacitance, inductivity, and/or active feedback. Here, we report that electrophoresis on paper─used, e.g., to electrophoretically driven lateral-flow immunoassays (LFIA)─can...
9.
Wang T, Ji H, Everton D, Le A, Krylova S, Fournier R, et al.
Anal Chem
. 2023 Oct;
95(42):15826-15832.
PMID: 37831482
The equilibrium constant of a chemical reaction is arguably the key thermodynamic parameter in chemistry; we naturally expect that equilibrium constants are determined accurately. The majority of equilibrium constants determined...
10.
Norris V, Olah J, Krylov S, Uversky V, Ovadi J
NPJ Syst Biol Appl
. 2023 Jul;
9(1):31.
PMID: 37433867
Intrinsically disordered proteins (IDPs), which can interact with many partner proteins, are central to many physiological functions and to various pathologies that include neurodegeneration. Here, we introduce the Sherpa hypothesis,...