Sergey N Krylov
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Explore the profile of Sergey N Krylov including associated specialties, affiliations and a list of published articles.
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162
Citations
1380
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Recent Articles
11.
Nebbioso G, Yosief R, Koshkin V, Qiu Y, Peng C, Elisseev V, et al.
PLoS One
. 2023 Jul;
18(7):e0282990.
PMID: 37399195
Cytometry of Reaction Rate Constant (CRRC) is a method for studying cell-population heterogeneity using time-lapse fluorescence microscopy, which allows one to follow reaction kinetics in individual cells. The current and...
12.
Panferov V, Ivanov N, Brinc D, Fabros A, Krylov S
ACS Sens
. 2023 Mar;
8(4):1792-1798.
PMID: 36988204
Serological assays detect the presence of specific antibodies in blood. There are urgent and important applications for serological point-of-care (POC) assays. However, available detection methods are either insufficiently sensitive or...
13.
Rukundo J, Latimer J, Jain S, Kochmann S, Krylov S
Anal Chem
. 2023 Feb;
95(7):3563-3568.
PMID: 36763923
The determination of accurate equilibrium dissociation constants, , of protein-small molecule complexes is important but challenging as all established methods have inherent sources of inaccuracy. Accurate Constant via Transient Incomplete...
14.
Electrophoresis-Assisted Multilayer Assembly of Nanoparticles for Sensitive Lateral Flow Immunoassay
Panferov V, Ivanov N, Mazzulli T, Brinc D, Kulasingam V, Krylov S
Angew Chem Int Ed Engl
. 2022 Nov;
62(2):e202215548.
PMID: 36357330
Lateral flow immunoassay (LFIA) is a rapid, simple, and inexpensive point-of-need method. A major limitation of LFIA is a high limit of detection (LOD), which impacts its diagnostic sensitivity. To...
15.
Teclemichael E, Le A, Krylova S, Wang T, Krylov S
Anal Chem
. 2022 Oct;
94(44):15183-15188.
PMID: 36302212
Selection of oligonucleotide aptamers involves consecutive rounds of affinity isolation of target-binding oligonucleotides from a random-sequence oligonucleotide library. Every next round produces an aptamer-enriched library with progressively higher fitness for...
16.
Wang T, Rukundo J, Le A, Ivanov N, Le Blanc J, Gorin B, et al.
Anal Chem
. 2022 Oct;
94(44):15415-15422.
PMID: 36301587
Large molecules can be generically separated from small ones, though partially and temporarily, in a pressure-driven flow inside a capillary. This transient incomplete separation has been only applied to species...
17.
Kochmann S, Ivanov N, Le Blanc J, Gorin B, Krylov S
Anal Chem
. 2022 Jun;
94(27):9519-9524.
PMID: 35767324
Molecular stream separation (MSS) is a promising complement for continuous-flow synthesis. MSS is driven by forces exerted on molecules by a field applied at an angle to the stream-carrying flow....
18.
Le A, Wang T, Krylova S, Beloborodov S, Krylov S
Anal Chem
. 2022 Jan;
94(5):2578-2588.
PMID: 35073041
Partitioning of protein-DNA complexes from protein-unbound DNA is a key step in selection of DNA aptamers. Conceptually, the partitioning step is characterized by two parameters: transmittance for protein-bound DNA (binders)...
19.
Rukundo J, Kochmann S, Wang T, Ivanov N, Le Blanc J, Gorin B, et al.
Anal Chem
. 2021 Aug;
93(34):11654-11659.
PMID: 34410698
Accurate Constant via Transient Incomplete Separation (ACTIS) is a new method for finding the equilibrium dissociation constant of a protein-small molecule complex based on transient incomplete separation of the complex...
20.
Koshkin V, De Oliveira M, Peng C, Ailles L, Liu G, Covens A, et al.
Mol Clin Oncol
. 2021 Jul;
15(2):161.
PMID: 34295468
A primary reason for chemotherapy failure is chemoresistance, which is driven by various mechanisms. Multi-drug resistance (MDR) is one such mechanism that is responsible for drug extrusion from the intracellular...