Sergey A Krupenko
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Explore the profile of Sergey A Krupenko including associated specialties, affiliations and a list of published articles.
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60
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2831
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Recent Articles
1.
Fu G, Molina S, Krupenko S, Sumner S, Rushing B
Metabolites
. 2024 Dec;
14(12).
PMID: 39728477
ALDH1L1 plays a crucial role in folate metabolism, regulating the flow of one-carbon groups through the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO in a NADP-dependent reaction. The downregulation of...
2.
Miller M, Douillet C, Cable P, Krupenko S, Shang B, Hartwell H, et al.
Toxicol Appl Pharmacol
. 2024 Nov;
495:117173.
PMID: 39603428
Arsenic (+3 oxidation state) methyltransferase (AS3MT) catalyzes the S-adenosylmethionine (SAM)-dependent methylation of inorganic arsenic (iAs), yielding monomethyl‑arsenic (MAs) and dimethyl‑arsenic (DMAs) metabolites. The formation of DMAs in this pathway is...
3.
You M, Shamseldin H, Fogle H, Rushing B, AlMalki R, Jaafar A, et al.
Clin Genet
. 2024 Jan;
105(5):488-498.
PMID: 38193334
ALDH1L2, a mitochondrial enzyme in folate metabolism, converts 10-formyl-THF (10-formyltetrahydrofolate) to THF (tetrahydrofolate) and CO. At the cellular level, deficiency of this NADP-dependent reaction results in marked reduction in NADPH/NADP...
4.
Bouch R, Zhang J, Miller B, Robbins C, Mosher T, Li W, et al.
J Exp Med
. 2023 Jun;
220(10).
PMID: 37367944
Th17 cells play a critical role in both tissue homeostasis and inflammation during clearance of infections as well as autoimmune and inflammatory disorders. Despite numerous efforts to distinguish the homeostatic...
5.
Pelligra A, Mrugala J, Griess K, Kirschner P, Nortmann O, Bartosinska B, et al.
Cell Rep
. 2023 Jun;
42(7):112703.
PMID: 37352100
No abstract available.
6.
Pelligra A, Mrugala J, Griess K, Kirschner P, Nortmann O, Bartosinska B, et al.
Cell Rep
. 2023 Jun;
42(6):112615.
PMID: 37294632
Type 2 diabetes is characterized by insulin hypersecretion followed by reduced glucose-stimulated insulin secretion (GSIS). Here we show that acute stimulation of pancreatic islets with the insulin secretagogue dextrorphan (DXO)...
7.
Rushing B, Fogle H, Sharma J, You M, McCormac J, Molina S, et al.
Molecules
. 2022 Dec;
27(23).
PMID: 36500483
Folate (vitamin B9) is involved in one-carbon transfer reactions and plays a significant role in nucleic acid synthesis and control of cellular proliferation, among other key cellular processes. It is...
8.
Sharma J, Rushing B, Hall M, Helke K, McRitchie S, Krupenko N, et al.
Metabolites
. 2022 May;
12(5).
PMID: 35629957
ALDH1L1 (10-formyltetrahydrofolate dehydrogenase), an enzyme of folate metabolism, is highly expressed in the liver. It regulates the overall flux of folate-bound one-carbon groups by converting 10-formyltetrahydrofolate to tetrahydrofolate and CO...
9.
Krupenko S, Cole S, Hou R, Haack K, Laston S, Mehta N, et al.
Am J Clin Nutr
. 2022 Apr;
116(2):500-510.
PMID: 35460232
Background: Glycine is a proteogenic amino acid that is required for numerous metabolic pathways, including purine, creatine, heme, and glutathione biosynthesis. Glycine formation from serine, catalyzed by serine hydroxy methyltransferase,...
10.
Tsybovsky Y, Sereda V, Golczak M, Krupenko N, Krupenko S
Commun Biol
. 2022 Jan;
5(1):3.
PMID: 35013550
Putative tumor suppressor ALDH1L1, the product of natural fusion of three unrelated genes, regulates folate metabolism by catalyzing NADP-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO. Cryo-EM structures of tetrameric...