Sean P Marrelli
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Explore the profile of Sean P Marrelli including associated specialties, affiliations and a list of published articles.
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56
Citations
874
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Recent Articles
1.
Sharina I, Awad R, Cobb S, Martin E, Marrelli S, Reddy A
Cell Rep Methods
. 2025 Feb;
5(2):100983.
PMID: 39954674
Non-invasive and high-temporal resolution methods for characterizing blood flow in mouse cranial arteries, such as the ophthalmic artery (OphA), are lacking. We present an application of pulsed Doppler ultrasound to...
2.
Kim G, Harmon E, Gutierrez M, Kim S, Vance L, Burrous H, et al.
Nat Commun
. 2025 Feb;
16(1):1639.
PMID: 39953063
Inflammation is a significant driver of ischemic stroke pathology in the brain. To identify potential regulators of inflammation, we performed single-cell RNA sequencing (scRNA-seq) of young and aged mouse brains...
3.
Escarcega R, M J V, Kyriakopoulos V, Ortiz G, Gusdon A, Fan H, et al.
Neurobiol Dis
. 2024 Dec;
204():106747.
PMID: 39617329
Alzheimer's disease (AD) affects more women than men. Although women live longer than men, it is not longevity alone, but other factors, including metabolic changes, that contribute to the higher...
4.
Escarcega R, Vijay Kumar M, Kyriakopoulos V, Ortiz G, Gusdon A, Fan H, et al.
bioRxiv
. 2024 Nov;
PMID: 39605322
Alzheimer's disease (AD) affects more women than men. Although women live longer than men, it is not longevity alone, but other factors, including metabolic changes, that contribute to the higher...
5.
Suarez C, Harb O, Robledo A, Largoza G, Ahn J, Alley E, et al.
bioRxiv
. 2024 May;
PMID: 38766159
Brain arteriovenous malformations (bAVMs) are direct connections between arteries and veins that remodel into a complex nidus susceptible to rupture and hemorrhage. Most sporadic bAVMs feature somatic activating mutations within...
6.
Ye Q, Jo J, Wang C, Oh H, Zhan J, Choy T, et al.
Cell Rep
. 2024 May;
43(5):114193.
PMID: 38709635
Astrocytes play vital roles in blood-brain barrier (BBB) maintenance, yet how they support BBB integrity under normal or pathological conditions remains poorly defined. Recent evidence suggests that ion homeostasis is...
7.
Zeineddine H, Hong S, Peesh P, Dienel A, Torres K, Thankamani Pandit P, et al.
Arterioscler Thromb Vasc Biol
. 2024 Feb;
44(3):635-652.
PMID: 38299355
Background: After subarachnoid hemorrhage (SAH), neutrophils are deleterious and contribute to poor outcomes. Neutrophils can produce neutrophil extracellular traps (NETs) after ischemic stroke. Our hypothesis was that, after SAH, neutrophils...
8.
Kaw A, Wu T, Starosolski Z, Zhou Z, Pedroza A, Majumder S, et al.
Res Sq
. 2023 Oct;
PMID: 37886459
pathogenic variants altering arginine 179 cause childhood-onset strokes due to moyamoya disease (MMD)-like occlusion of the distal internal carotid arteries. A smooth muscle cell (SMC)-specific knock-in mouse model () inserted...
9.
Nguyen J, Mohan E, Pandya G, Ali U, Tan C, Kofler J, et al.
J Neuroinflammation
. 2023 Oct;
20(1):232.
PMID: 37817190
Introduction: Acute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate to the brain, thereby aggravating injury. Chronically after stroke, repair processes, including angiogenesis,...
10.
Escarcega R, Patil A, Moruno-Manchon J, Urayama A, Marrelli S, Kim N, et al.
J Biol Chem
. 2023 Aug;
299(10):105157.
PMID: 37579947
Noncanonical base pairing between four guanines (G) within single-stranded G-rich sequences leads to formation of а G-quartet. Self-stacking of G-quartets results in a columnar four-stranded DNA structure known as the...