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Gab Seok Kim

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Articles 27
Citations 1339
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Recent Articles
1.
Kim G, Harmon E, Gutierrez M, Kim S, Vance L, Burrous H, et al.
Nat Commun . 2025 Feb; 16(1):1639. PMID: 39953063
Inflammation is a significant driver of ischemic stroke pathology in the brain. To identify potential regulators of inflammation, we performed single-cell RNA sequencing (scRNA-seq) of young and aged mouse brains...
2.
Tashiro R, Ozaki D, Bautista-Garrido J, Sun G, Obertas L, Mobley A, et al.
Int J Mol Sci . 2023 Mar; 24(6). PMID: 36982260
Aging drives cognitive decline, and mitochondrial dysfunction is a hallmark of age-induced neurodegeneration. Recently, we demonstrated that astrocytes secrete functional mitochondria (Mt), which help adjacent cells to resist damage and...
3.
Kim G, Harmon E, Gutierrez M, Stephenson J, Chauhan A, Banerjee A, et al.
Res Sq . 2023 Feb; PMID: 36824976
Microglia are key mediators of inflammatory responses within the brain, as they regulate pro-inflammatory responses while also limiting neuroinflammation via reparative phagocytosis. Thus, identifying genes that modulate microglial function may...
4.
Harmon E, Doan A, Bautista-Garrido J, Jung J, Marrelli S, Kim G
Int J Mol Sci . 2022 Aug; 23(16). PMID: 36012150
Microglia, the resident innate immune cells of the brain, become more highly reactive with aging and diseased conditions. In collaboration with other cell types in brains, microglia can contribute both...
5.
Tashiro R, Bautista-Garrido J, Ozaki D, Sun G, Obertas L, Mobley A, et al.
J Neurosci . 2022 Aug; 42(36):7001-7014. PMID: 35970559
Astrocytes release functional mitochondria (Mt) that play regulatory and prosurvival functions on entering adjacent cells. We recently demonstrated that these released Mts could enter microglia to promote their reparative/prophagocytic phenotype...
6.
Kim G, Stephenson J, Al Mamun A, Wu T, Goss M, Min J, et al.
Sci Rep . 2021 Jun; 11(1):12613. PMID: 34131204
Secondary injury following cortical stroke includes delayed gliosis and eventual neuronal loss in the thalamus. However, the effects of aging and the potential to ameliorate this gliosis with NMDA receptor...
7.
Uzor N, Scheihing D, Kim G, Moruno-Manchon J, Zhu L, Reynolds C, et al.
Mol Cell Neurosci . 2020 Aug; 107:103536. PMID: 32777345
Peroxisomes exist in nearly every cell, oxidizing fats, synthesizing lipids and maintaining redox balance. As the brain ages, multiple pathways are negatively affected, but it is currently unknown if peroxisomal...
8.
Min J, Bu F, Qi L, Munshi Y, Kim G, Marrelli S, et al.
Int J Mol Sci . 2019 Apr; 20(9). PMID: 31027360
Neonatal hypoxia-ischemia (HI) is a major cause of death and disability in neonates. HI leads to a dramatic rise in intracellular calcium levels, which was originally thought to be detrimental...
9.
Kim G, Yang L, Zhang G, Zhao H, Selim M, McCullough L, et al.
Nat Commun . 2015 Aug; 6:7893. PMID: 26243335
The use and effectiveness of current stroke reperfusion therapies are limited by the complications of reperfusion injury, which include increased cerebrovascular permeability and haemorrhagic transformation. Sphingosine-1-phosphate (S1P) is emerging as...
10.
Kim G, Cho S, Nelson J, Zipfel G, Han B
PLoS One . 2014 Feb; 9(2):e88962. PMID: 24551199
Perinatal hypoxic ischemia (H-I) causes brain damage and long-term neurological impairments, leading to motor dysfunctions and cerebral palsy. Many studies have demonstrated that the TrkB-ERK1/2 signaling pathway plays a key...