Sean P Garrison
Overview
Explore the profile of Sean P Garrison including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
609
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0
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Recent Articles
1.
Bernstein A, Garrison S, Zambetti G, OMalley K
Mol Neurodegener
. 2011 Jan;
6(1):2.
PMID: 21211034
Background: Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN), resulting in tremor, rigidity, and bradykinesia. Although the etiology is unknown, insight...
2.
Garrison S, Thornton J, Hacker H, Webby R, Rehg J, Parganas E, et al.
PLoS Pathog
. 2011 Jan;
6(12):e1001240.
PMID: 21203486
Disruption of p53/Puma-mediated apoptosis protects against lethality due to DNA damage. Here we demonstrate the unexpected requirement of the pro-apoptotic p53-target gene Puma to mount a successful innate immune response...
3.
Coloff J, Mason E, Altman B, Gerriets V, Liu T, Nichols A, et al.
J Biol Chem
. 2010 Dec;
286(7):5921-33.
PMID: 21159778
The PI3K/Akt pathway is activated in stimulated cells and in many cancers to promote glucose metabolism and prevent cell death. Although inhibition of Akt-mediated cell survival may provide a means...
4.
Yu H, Shen H, Yuan Y, Xufeng R, Hu X, Garrison S, et al.
Blood
. 2010 Feb;
115(17):3472-80.
PMID: 20177048
Molecular paradigms underlying the death of hematopoietic stem cells (HSCs) induced by ionizing radiation are poorly defined. We have examined the role of Puma (p53 up-regulated mediator of apoptosis) in...
5.
Cazanave S, Mott J, Elmi N, Bronk S, Werneburg N, Akazawa Y, et al.
J Biol Chem
. 2009 Jul;
284(39):26591-602.
PMID: 19638343
Free fatty acids (FFA) induce hepatocyte lipoapoptosis by a c-Jun N-terminal kinase (JNK)-dependent mechanism. However, the cellular processes by which JNK engages the core apoptotic machinery during lipotoxicity, especially activation...
6.
Phillips D, Garrison S, Jeffers J, Zambetti G
Methods Mol Biol
. 2009 Jul;
559:143-59.
PMID: 19609755
Paramount to the maintenance of normal tissue homeostasis is the induction of programmed cell death, otherwise known as apoptosis. Several disease states, including cancer, are characterized by an inability to...
7.
Garrison S, Jeffers J, Yang C, Nilsson J, Hall M, Rehg J, et al.
Mol Cell Biol
. 2008 Jun;
28(17):5391-402.
PMID: 18573879
The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate...
8.
Wu W, Heinrichs S, Xu D, Garrison S, Zambetti G, Adams J, et al.
Cell
. 2005 Nov;
123(4):641-53.
PMID: 16286009
In response to DNA damage, the p53 tumor suppressor can elicit either apoptosis or cell-cycle arrest and repair, but how this critical decision is made in specific cell types remains...