John R Jeffers
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Explore the profile of John R Jeffers including associated specialties, affiliations and a list of published articles.
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11
Citations
1729
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Recent Articles
1.
Jeffers J, Pinto E, Rehg J, Clay M, Wang J, Neale G, et al.
Cancer Res
. 2021 Feb;
81(9):2442-2456.
PMID: 33637564
The TP53-R337H founder mutation exists at a high frequency throughout southern Brazil and represents one of the most common germline TP53 mutations reported to date. It was identified in pediatric...
2.
Rao S, Lee S, Gutierrez A, Perrigoue J, Thapa R, Tu Z, et al.
Blood
. 2012 Sep;
120(18):3764-73.
PMID: 22976955
Ribosomal protein (RP) mutations in diseases such as 5q- syndrome both disrupt hematopoiesis and increase the risk of developing hematologic malignancy. However, the mechanism by which RP mutations increase cancer...
3.
Lake B, Fink J, Klemetsaune L, Fu X, Jeffers J, Zambetti G, et al.
Stem Cells
. 2012 Feb;
30(5):888-97.
PMID: 22311782
Reprogramming of the somatic state to pluripotency can be induced by a defined set of transcription factors including Oct3/4, Sox2, Klf4, and c-Myc [Cell 2006;126:663-676]. These induced pluripotent stem cells...
4.
Kuribayashi K, Finnberg N, Jeffers J, Zambetti G, El-Deiry W
Cell Cycle
. 2011 Jun;
10(14):2380-9.
PMID: 21709442
The p53 pathway displays a large degree of redundancy in the expression of a number of pro-apoptotic mechanisms following DNA damage that, among others, involves increased expression of several pro-apoptotic...
5.
Ren D, Tu H, Kim H, Wang G, Bean G, Takeuchi O, et al.
Science
. 2010 Dec;
330(6009):1390-3.
PMID: 21127253
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated remains unsettled. We provide in vivo evidence demonstrating an...
6.
Kim H, Tu H, Ren D, Takeuchi O, Jeffers J, Zambetti G, et al.
Mol Cell
. 2009 Nov;
36(3):487-99.
PMID: 19917256
While activation of BAX/BAK by BH3-only molecules (BH3s) is essential for mitochondrial apoptosis, the underlying mechanisms remain unsettled. Here we demonstrate that BAX undergoes stepwise structural reorganization leading to mitochondrial...
7.
Phillips D, Garrison S, Jeffers J, Zambetti G
Methods Mol Biol
. 2009 Jul;
559:143-59.
PMID: 19609755
Paramount to the maintenance of normal tissue homeostasis is the induction of programmed cell death, otherwise known as apoptosis. Several disease states, including cancer, are characterized by an inability to...
8.
Garrison S, Jeffers J, Yang C, Nilsson J, Hall M, Rehg J, et al.
Mol Cell Biol
. 2008 Jun;
28(17):5391-402.
PMID: 18573879
The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate...
9.
Kim H, Rafiuddin-Shah M, Tu H, Jeffers J, Zambetti G, Hsieh J, et al.
Nat Cell Biol
. 2006 Nov;
8(12):1348-58.
PMID: 17115033
Although the BCL-2 family constitutes a crucial checkpoint in apoptosis, the intricate interplay between these family members remains elusive. Here, we demonstrate that BIM and PUMA, similar to truncated BID...
10.
Toth A, Jeffers J, Nickson P, Min J, Morgan J, Zambetti G, et al.
Am J Physiol Heart Circ Physiol
. 2006 Jan;
291(1):H52-60.
PMID: 16399862
The p53-upregulated modulator of apoptosis (Puma), a BH3-only member of the Bcl-2 protein family, is required for p53-dependent and -independent forms of apoptosis and has been implicated in the pathomechanism...