Sean C Purcell
Overview
Explore the profile of Sean C Purcell including associated specialties, affiliations and a list of published articles.
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7
Citations
73
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Recent Articles
1.
Trieger G, Pessentheiner A, Purcell S, Green C, DeForest N, Willert K, et al.
J Biol Chem
. 2023 Mar;
299(5):104611.
PMID: 36931394
Adipose tissue plays a crucial role in maintaining metabolic homeostasis by storing lipids and glucose from circulation as intracellular fat. As peripheral tissues like adipose tissue become insulin resistant, decompensation...
2.
Purcell S, Zhang M, Honigfort D, Ng H, Michalak A, Godula K
Chem Sci
. 2022 Jun;
13(22):6626-6635.
PMID: 35756522
The cellular glycocalyx, composed of membrane associated glycoproteins and glycolipids, is a complex and dynamic interface that facilitates interactions between cells and their environment. The glycocalyx composition is continuously changing...
3.
Porell R, Follmar J, Purcell S, Timm B, Laubach L, Kozirovskiy D, et al.
ACS Chem Biol
. 2022 May;
17(6):1534-1542.
PMID: 35574759
Glycosaminoglycans (GAGs) are a class of highly negatively charged membrane-associated and extracellular matrix polysaccharides involved in the regulation of myriad biological functions, including cell adhesion, migration, signaling, and differentiation, among...
4.
Naticchia M, Laubach L, Honigfort D, Purcell S, Godula K
Biomater Sci
. 2021 Jan;
9(5):1652-1659.
PMID: 33409513
Growth factor (GF) patterning in stem cell spheroids, such as embryoid bodies (EBs), has been sought to guide their differentiation and organization into functional 3D tissue models and organoids. Current...
5.
Purcell S, Godula K
Interface Focus
. 2019 Mar;
9(2):20180080.
PMID: 30842878
The glycocalyx is an information-dense network of biomacromolecules extensively modified through glycosylation that populates the cellular boundary. The glycocalyx regulates biological events ranging from cellular protection and adhesion to signalling...
6.
Spiciarich D, Nolley R, Maund S, Purcell S, Herschel J, Iavarone A, et al.
Angew Chem Int Ed Engl
. 2017 Jun;
56(31):8992-8997.
PMID: 28649697
Sialylated glycans are found at elevated levels in many types of cancer and have been implicated in disease progression. However, the specific glycoproteins that contribute to the cancer cell-surface sialylation...
7.
Huang M, Purcell S, Verespy III S, Wang Y, Godula K
Biomater Sci
. 2017 Jun;
5(8):1537-1540.
PMID: 28616946
We report a method for programming complexity into the glycocalyx of live cells. Via a combination of glycomaterial synthesis and membrane remodeling, we have engineered cells to display native-like, mixed...