Scott W Canna
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Explore the profile of Scott W Canna including associated specialties, affiliations and a list of published articles.
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76
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3911
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Recent Articles
1.
Duran J, Sayed S, Dalalo M, Mauracher A, Knight M, Conrey P, et al.
bioRxiv
. 2024 Dec;
PMID: 39713308
Signal transduction downstream of activating stimuli controls CD8+ T cell biology, however these external inputs can become uncoupled from transcriptional regulation in Primary Immune Regulatory Disorders (PIRDs). Gain-of-function (GOF) variants...
2.
Grayczyk J, Liu L, Egan M, Aunins E, Wynosky-Dolfi M, Canna S, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(48):e2412700121.
PMID: 39556752
NLR family, apoptosis inhibitory proteins (NAIPs) detect bacterial flagellin and structurally related components of bacterial type III secretion systems (T3SS), and recruit NLR family CARD domain containing protein 4 (NLRC4)...
3.
Zhang M, Cron R, Chu N, Nguyen J, Gordon S, Eloseily E, et al.
J Allergy Clin Immunol
. 2024 Oct;
155(3):1015-1026.e5.
PMID: 39423879
Background: Cytokine storm syndromes (CSSs), including hemophagocytic lymphohistiocytosis (HLH), are increasingly recognized as hyperinflammatory states leading to multiorgan failure and death. Familial HLH in infancy results from homozygous genetic defects...
4.
Gallo P, Kim J, McNerney K, Diorio C, Foley C, Kagami L, et al.
J Allergy Clin Immunol
. 2024 Sep;
155(2):594-604.e5.
PMID: 39303891
Background: Cytokines are soluble signaling proteins that regulate inflammation and coordinate immune responses. Serum cytokine panels are increasingly used in medical practice, yet our understanding of cytokines as biomarkers for...
5.
Carol H, Mayer A, Zhang M, Dang V, Varghese J, Martinez Z, et al.
J Clin Immunol
. 2024 Sep;
45(1):4.
PMID: 39264477
High ferritin is an important and sensitive biomarker for the various forms of hemophagocytic lymphohistiocytosis (HLH), a diverse and deadly group of cytokine storm syndromes. Early action to prevent immunopathology...
6.
Canna S
Adv Exp Med Biol
. 2024 Aug;
1448:385-397.
PMID: 39117828
Cytokine Storm is a complex and heterogeneous state of life-threatening systemic inflammation and immunopathology. Autoinflammation is a mechanistic category of immune dysregulation wherein immunopathology originates due to poor regulation of...
7.
Vastert S, Canny S, Canna S, Schneider R, Mellins E
Adv Exp Med Biol
. 2024 Aug;
1448:323-353.
PMID: 39117825
The cytokine storm syndrome (CSS) associated with systemic juvenile idiopathic arthritis (sJIA) has widely been referred to as macrophage activation syndrome (MAS). In this chapter, we use the term sJIA-associated...
8.
Henter J, Sieni E, Eriksson J, Bergsten E, Hed Myrberg I, Canna S, et al.
Blood
. 2024 Jul;
144(22):2308-2318.
PMID: 39046779
Current hemophagocytic lymphohistiocytosis 2004 (HLH-2004)-based diagnostic criteria for familial hemophagocytic lymphohistiocytosis (FHL) are based on expert opinion. Here, we performed a case-control study to test and possibly improve these criteria....
9.
Carol H, Mayer A, Zhang M, Dang V, Varghese J, Martinez Z, et al.
Res Sq
. 2024 Jul;
PMID: 38978562
High ferritin is an important and sensitive biomarker for hemophagocytic lymphohistiocytosis (HLH), a diverse and deadly group of cytokine storm syndromes. Early action to prevent immunopathology in HLH often includes...
10.
Domblides C, Crampton S, Liu H, Bartleson J, Nguyen A, Champagne C, et al.
J Clin Invest
. 2024 Apr;
134(11).
PMID: 38652550
The immune system can control cancer progression. However, even though some innate immune sensors of cellular stress are expressed intrinsically in epithelial cells, their potential role in cancer aggressiveness and...