Scott W Canna
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Explore the profile of Scott W Canna including associated specialties, affiliations and a list of published articles.
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76
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3911
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Recent Articles
11.
Bhuiyan M, Habib K, Sultan M, Chen F, Jahan I, Weng Z, et al.
CNS Neurosci Ther
. 2024 Mar;
30(3):e14654.
PMID: 38433018
Background: Astrogliosis and white matter lesions (WML) are key characteristics of vascular contributions to cognitive impairment and dementia (VCID). However, the molecular mechanisms underlying VCID remain poorly understood. Stimulation of...
12.
Grom A, Canna S, Abu-Arja R, Sinha R, Peixoto L, Cannizzaro E, et al.
Pediatr Rheumatol Online J
. 2024 Jan;
21(Suppl 1):86.
PMID: 38183096
It has been increasingly recognized that there is a subset of patients with refractory systemic JIA, who have failed all available medications and may benefit from HSCT. The increasing experience...
13.
Canna S, De Benedetti F
Pediatr Rheumatol Online J
. 2024 Jan;
21(Suppl 1):79.
PMID: 38183056
Since IL-18 has recently emerged as a biomarker associated with refractory disease course in SJIA, the focus of the discussion was the feasibility of the biomarker-driven drug development to SJIA....
14.
Huang Z, Brodeur K, Chen L, Du Y, Wobma H, Hsu E, et al.
J Clin Invest
. 2023 Sep;
133(22).
PMID: 37751296
BACKGROUNDMacrophage activation syndrome (MAS) is a life-threatening complication of Still's disease (SD) characterized by overt immune cell activation and cytokine storm. We aimed to further understand the immunologic landscape of...
15.
Landy E, Varghese J, Dang V, Szymczak-Workman A, Kane L, Canna S
Blood Adv
. 2023 Sep;
7(22):6949-6963.
PMID: 37738167
Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening hyperinflammatory syndromes. Familial HLH is caused by genetic impairment of granule-mediated cytotoxicity (eg, perforin deficiency). MAS is linked to excess...
16.
Shakoory B, Geerlinks A, Wilejto M, Kernan K, Hines M, Romano M, et al.
Ann Rheum Dis
. 2023 Jul;
82(10):1271-1285.
PMID: 37487610
Objective: Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can develop in most inflammatory contexts. They can progress rapidly, and early identification and management...
17.
Shakoory B, Geerlinks A, Wilejto M, Kernan K, Hines M, Romano M, et al.
Arthritis Rheumatol
. 2023 Jul;
75(10):1714-1732.
PMID: 37486733
Objective: Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening systemic hyperinflammatory syndromes that can develop in most inflammatory contexts. They can progress rapidly, and early identification and management...
18.
Fan Z, Kernan K, Sriram A, Benos P, Canna S, Carcillo J, et al.
Gigascience
. 2023 Jul;
12.
PMID: 37395630
Background: Learning the causal structure helps identify risk factors, disease mechanisms, and candidate therapeutics for complex diseases. However, although complex biological systems are characterized by nonlinear associations, existing bioinformatic methods...
19.
Diorio C, Teachey D, Canna S
J Allergy Clin Immunol Pract
. 2023 Mar;
11(6):1636-1644.
PMID: 36990432
Cytokine storm syndromes (CSS) represent a diverse group of disorders characterized by severe overactivation of the immune system. In the majority of patients, CSS arise from a combination of host...
20.
Huang Z, You X, Chen L, Du Y, Brodeur K, Jee H, et al.
Nat Commun
. 2022 Nov;
13(1):6915.
PMID: 36443301
Still's disease is a severe inflammatory syndrome characterized by fever, skin rash and arthritis affecting children and adults. Patients with Still's disease may also develop macrophage activation syndrome, a potentially...