Scott P Heximer
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Explore the profile of Scott P Heximer including associated specialties, affiliations and a list of published articles.
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47
Citations
1225
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Recent Articles
11.
Hadipour-Lakmehsari S, Driouchi A, Lee S, Kuzmanov U, Callaghan N, Heximer S, et al.
Sci Rep
. 2019 May;
9(1):7867.
PMID: 31133706
Pathological cardiac hypertrophy is a debilitating condition characterized by deleterious thickening of the myocardium, dysregulated Ca signaling within cardiomyocytes, and contractile dysfunction. Importantly, the nanoscale organization, localization, and patterns of...
12.
Blaser M, Wei K, Adams R, Zhou Y, Caruso L, Mirzaei Z, et al.
Circ Res
. 2017 Dec;
122(3):405-416.
PMID: 29273600
Rationale: Aortic valve disease is a cell-mediated process without effective pharmacotherapy. CNP (C-type natriuretic peptide) inhibits myofibrogenesis and osteogenesis of cultured valve interstitial cells and is downregulated in stenotic aortic...
13.
Baggio L, Ussher J, McLean B, Cao X, Kabir M, Mulvihill E, et al.
Mol Metab
. 2017 Nov;
6(11):1339-1349.
PMID: 29107282
Objectives: Glucagon-like peptide-1 (GLP-1) is secreted from enteroendocrine cells and exerts a broad number of metabolic actions through activation of a single GLP-1 receptor (GLP-1R). The cardiovascular actions of GLP-1...
14.
Kroetsch J, Levy A, Zhang H, Aschar-Sobbi R, Lidington D, Offermanns S, et al.
Nat Commun
. 2017 Apr;
8:14805.
PMID: 28378814
Tumour necrosis factor (TNF) is a ubiquitously expressed cytokine with functions beyond the immune system. In several diseases, the induction of TNF expression in resistance artery smooth muscle cells enhances...
15.
Bastin G, Yang J, Heximer S
Front Bioeng Biotechnol
. 2015 Sep;
3:128.
PMID: 26389115
Heterotrimeric G-protein signaling has been shown to modulate a wide variety of intracellular signaling pathways, including the mitogen-activated protein kinase (MAPK) family. The activity of one MAPK family class, c-Jun...
16.
Liu J, Kim K, Morales M, Heximer S, Hui C, Backx P
PLoS One
. 2015 Jul;
10(7):e0133274.
PMID: 26196737
Gradients of the fast transient outward K+ current (Ito,f) contribute to heterogeneity of ventricular repolarization in a number of species. Cardiac Ito,f levels and gradients change notably with heart disease....
17.
Guo J, Breen D, Pereira T, Dalvi P, Zhang H, Mori Y, et al.
Atherosclerosis
. 2015 May;
241(1):111-20.
PMID: 25974101
In vitro, insulin has mitogenic effects on vascular smooth muscle cells (VSMC) but also has protective effects on endothelial cells by stimulating nitric oxide (NO) production and endothelial nitric oxide...
18.
Momen A, Afroze T, Sadi A, Khoshbin A, Zhang H, Choi J, et al.
J Recept Signal Transduct Res
. 2014 May;
34(6):476-83.
PMID: 24846582
Context: Regulator of G-protein signaling-2 (RGS2) inhibits Gq-mediated regulation of Ca(2+) signalling in vascular smooth muscle cells (VSMC). Objective: RGS2 knockout (RGS2KO) mice are hypertensive and show arteriolar remodeling. VSMC...
19.
Proulx E, Suri D, Heximer S, Vaidya V, Lambe E
Biol Psychiatry
. 2013 Dec;
76(4):315-23.
PMID: 24315552
Background: The experience of early stress contributes to the etiology of several psychiatric disorders and can lead to lasting deficits in working memory and attention. These executive functions require activation...
20.
Bastin G, Heximer S
J Biol Chem
. 2013 Jun;
288(30):21836-49.
PMID: 23733193
RGS4, a heterotrimeric G-protein inhibitor, localizes to plasma membrane (PM) and endosomal compartments. Here, we examined Rab-mediated control of RGS4 internalization and recycling. Wild type and constitutively active Rab5 decreased...