Robert P Mecham
Overview
Explore the profile of Robert P Mecham including associated specialties, affiliations and a list of published articles.
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Articles
162
Citations
5486
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0
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Recent Articles
1.
Lin C, Keating C, Roth R, Caliskan Y, Nazzal M, Exil V, et al.
J Cardiovasc Dev Dis
. 2024 Nov;
11(11).
PMID: 39590192
Thoracic and abdominal aortic aneurysms (TAAs and AAAs, respectively) share morphological features but have distinct clinical and hereditary characteristics. Studies using bulk RNA comparisons revealed distinct patterns of gene expression...
2.
Bodmer N, Knutsen R, Roth R, Castile R, Brodt M, Gierasch C, et al.
Dev Dyn
. 2023 Sep;
253(2):233-254.
PMID: 37688792
Background: Latent TGFβ binding protein-2 (LTBP2) is a fibrillin 1 binding component of the microfibril. LTBP2 is the only LTBP protein that does not bind any isoforms of TGFβ, although...
3.
Kailash K, Hawes J, Cocciolone A, Bersi M, Mecham R, Wagenseil J
J Biomech Eng
. 2023 Aug;
146(5).
PMID: 37646627
Arterial stiffening occurs during natural aging, is associated with an increased risk of adverse cardiovascular events, and can follow different timelines in males and females. One mechanism of arterial stiffening...
4.
Ruddiman C, Peckham R, Luse M, Chen Y, Kuppusamy M, Corliss B, et al.
JCI Insight
. 2023 Apr;
8(9).
PMID: 37014698
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular...
5.
Elenbaas J, Pudupakkam U, Ashworth K, Kang C, Patel V, Santana K, et al.
Nat Commun
. 2023 Mar;
14(1):1511.
PMID: 36932061
No abstract available.
6.
Elenbaas J, Pudupakkam U, Ashworth K, Kang C, Patel V, Santana K, et al.
Nat Commun
. 2023 Feb;
14(1):850.
PMID: 36792666
Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an extracellular matrix protein that causally promotes vascular disease and associates with platelet reactivity in humans....
7.
Brengle B, Lin M, Roth R, Jones K, Wagenseil J, Mecham R, et al.
Matrix Biol
. 2023 Feb;
117:1-14.
PMID: 36773748
Supravalvular aortic stenosis (SVAS) is an autosomal dominant disease resulting from elastin (ELN) haploinsufficiency. Individuals with SVAS typically develop a thickened arterial media with an increased number of elastic lamellae...
8.
Dayal S, Broekelmann T, Mecham R, Ramamurthi A
Tissue Eng Part A
. 2023 Jan;
29(7-8):187-199.
PMID: 36641641
Abdominal aortic aneurysms (AAAs) represent a multifactorial, proteolytic disorder involving disintegration of the matrix structure within the AAA wall. Intrinsic deficiency of adult vascular cells to regenerate and repair the...
9.
Coll-Bonfill N, Mahajan U, Shashkova E, Lin C, Mecham R, Gonzalo S
Geroscience
. 2022 Dec;
45(2):965-982.
PMID: 36482259
Hutchinson-Gilford progeria syndrome is a premature aging disease caused by LMNA gene mutation and the production of a truncated prelamin A protein "progerin" that elicits cellular and organismal toxicity. Progerin...
10.
Crandall C, Kim S, Rother J, Lee V, Mecham R, Wagenseil J
J Biomech
. 2022 Nov;
145:111360.
PMID: 36334323
Large elastic arteries, such as the aorta, contain concentric layers of elastic laminae composed mainly of the extracellular matrix protein elastin. The structure of the elastic laminae could affect transmural...