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Scott P Ginebaugh

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Recent Articles
1.
Ginebaugh S, Badawi Y, Laghaei R, Mersky G, Wallace C, Tarr T, et al.
J Neurophysiol . 2023 Apr; 129(5):1259-1277. PMID: 37073966
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune-mediated neuromuscular disease thought to be caused by autoantibodies against P/Q-type voltage-gated calcium channels (VGCCs), which attack and reduce the number of VGCCs within...
2.
Ginebaugh S, Hagner M, Ray A, Erzurum S, Comhair S, Denlinger L, et al.
J Allergy Clin Immunol . 2023 Feb; 151(6):1513-1524. PMID: 36796454
Background: Inhaled corticosteroids (CSs) are the backbone of asthma treatment, improving quality of life, exacerbation rates, and mortality. Although effective for most, a subset of patients with asthma experience CS-resistant...
3.
Williams H, Dias Costa A, Zhang J, Raghavan S, Winter P, Kapner K, et al.
Cancer Res . 2022 Dec; 83(3):441-455. PMID: 36459568
Significance: A high-throughput pipeline using multiplex immunofluorescence in pancreatic cancer reveals striking expression subtype intratumoral heterogeneity with implications for therapy selection and identifies co-expressor cells that may serve as intermediates...
4.
Ginebaugh S, Badawi Y, Tarr T, Meriney S
Biomolecules . 2022 Jun; 12(6). PMID: 35740866
The mouse neuromuscular junction (NMJ) has long been used as a model synapse for the study of neurotransmission in both healthy and disease states of the NMJ. Neurotransmission from these...
5.
Nagasaki T, Schuyler A, Zhao J, Samovich S, Yamada K, Deng Y, et al.
J Clin Invest . 2021 Nov; 132(1). PMID: 34762602
Altered redox biology challenges all cells, with compensatory responses often determining a cell's fate. When 15 lipoxygenase 1 (15LO1), a lipid-peroxidizing enzyme abundant in asthmatic human airway epithelial cells (HAECs),...
6.
Ojala K, Ginebaugh S, Wu M, Miller E, Ortiz G, Covarrubias M, et al.
J Biol Chem . 2021 Jan; 296:100302. PMID: 33465376
3,4-Diaminopyridine (3,4-DAP) increases transmitter release from neuromuscular junctions (NMJs), and low doses of 3,4-DAP (estimated to reach ∼1 μM in serum) are the Food and Drug Administration (FDA)-approved treatment for...
7.
Ginebaugh S, Cyphers E, Lanka V, Ortiz G, Miller E, Laghaei R, et al.
J Neurosci . 2020 Apr; 40(18):3504-3516. PMID: 32265260
The action potential (AP) waveform controls the opening of voltage-gated calcium channels and contributes to the driving force for calcium ion flux that triggers neurotransmission at presynaptic nerve terminals. Although...