Tyler B Tarr
Overview
Explore the profile of Tyler B Tarr including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
189
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0
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Recent Articles
1.
Kang J, Schroeder M, Lee Y, Kapoor C, Yu E, Tarr T, et al.
Nat Commun
. 2024 Nov;
15(1):9722.
PMID: 39521775
Proteins work together in nanostructures in many physiological contexts and disease states. We recently developed expansion revealing (ExR), which expands proteins away from each other, in order to support better...
2.
Ginebaugh S, Badawi Y, Laghaei R, Mersky G, Wallace C, Tarr T, et al.
J Neurophysiol
. 2023 Apr;
129(5):1259-1277.
PMID: 37073966
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune-mediated neuromuscular disease thought to be caused by autoantibodies against P/Q-type voltage-gated calcium channels (VGCCs), which attack and reduce the number of VGCCs within...
3.
Sarkar D, Kang J, Wassie A, Schroeder M, Peng Z, Tarr T, et al.
Nat Biomed Eng
. 2022 Aug;
6(9):1057-1073.
PMID: 36038771
Many crowded biomolecular structures in cells and tissues are inaccessible to labelling antibodies. To understand how proteins within these structures are arranged with nanoscale precision therefore requires that these structures...
4.
Ginebaugh S, Badawi Y, Tarr T, Meriney S
Biomolecules
. 2022 Jun;
12(6).
PMID: 35740866
The mouse neuromuscular junction (NMJ) has long been used as a model synapse for the study of neurotransmission in both healthy and disease states of the NMJ. Neurotransmission from these...
5.
Held R, Liu C, Ma K, Ramsey A, Tarr T, de Nola G, et al.
Neuron
. 2020 Jul;
107(4):667-683.e9.
PMID: 32616470
Presynaptic Ca2 channels are essential for Ca-triggered exocytosis. In addition, there are two competing models for their roles in synapse structure. First, Ca channels or Ca entry may control synapse...
6.
Laghaei R, Ma J, Tarr T, Homan A, Kelly L, Tilvawala M, et al.
J Neurophysiol
. 2018 Jan;
119(4):1340-1355.
PMID: 29357458
We have investigated the impact of transmitter release site (active zone; AZ) structure on synaptic function by physically rearranging the individual AZ elements in a previously published frog neuromuscular junction...
7.
Meriney S, Tarr T, Ojala K, Wu M, Li Y, Lacomis D, et al.
Ann N Y Acad Sci
. 2017 Nov;
1412(1):73-81.
PMID: 29125190
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder caused by antibodies directed against the voltage-gated calcium channels that provide the calcium ion flux that triggers acetylcholine release at the neuromuscular...
8.
Tarr T, Wipf P, Meriney S
Mol Neurobiol
. 2014 Sep;
52(1):456-63.
PMID: 25195700
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that disrupts the normally reliable neurotransmission at the neuromuscular junction (NMJ). This disruption is thought to result from an autoantibody-mediated removal of...
9.
Tarr T, Lacomis D, Reddel S, Liang M, Valdomir G, Frasso M, et al.
J Physiol
. 2014 Jul;
592(16):3687-96.
PMID: 25015919
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder in which a significant fraction of the presynaptic P/Q-type Ca(2+) channels critical to the triggering of neurotransmitter release at the neuromuscular junction...
10.
Liang M, Tarr T, Bravo-Altamirano K, Valdomir G, Rensch G, Swanson L, et al.
ACS Med Chem Lett
. 2014 Jun;
3(12):985-90.
PMID: 24936234
The acute effect of the potent cyclin-dependent kinase (cdk) inhibitor (R)-roscovitine on Ca(2+) channels inspired the development of structural analogues as a potential treatment for motor nerve terminal dysfunction. On...