Scott Horowitz
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Explore the profile of Scott Horowitz including associated specialties, affiliations and a list of published articles.
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46
Citations
1138
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Recent Articles
1.
Kallweit L, Hamlett E, Saternos H, Gilmore A, Granholm A, Horowitz S
Elife
. 2025 Feb;
14.
PMID: 39992714
As the world population ages, new molecular targets in aging and Alzheimer's disease (AD) are needed to combat the expected influx of new AD cases. Until now, the role of...
2.
Huang Z, Ghosh K, Stull F, Horowitz S
Proc Natl Acad Sci U S A
. 2025 Feb;
122(6):e2414045122.
PMID: 39913211
Many proteins have slow folding times in vitro that are physiologically untenable. To combat this challenge, ATP-dependent chaperonins are thought to possess the unique ability to catalyze protein folding. Performing...
3.
Litberg T, Horowitz S
ACS Chem Biol
. 2024 Mar;
19(4):809-823.
PMID: 38477936
The role of nucleic acids in protein folding and aggregation is an area of continued research, with relevance to understanding both basic biological processes and disease. In this review, we...
4.
Son A, Smetana J, Horowitz S, Lennon C
Protein Sci
. 2024 Feb;
33(3):e4925.
PMID: 38380775
Biosensors to measure protein stability in vivo are valuable tools for a variety of applications. Previous work has demonstrated that a tripartite design, whereby a protein of interest (POI) is...
5.
Kallweit L, Hamlett E, Hamlett E, Saternos H, Gilmore A, Granholm A, et al.
bioRxiv
. 2023 Oct;
PMID: 37873355
Introduction: As the world population ages, new molecular targets in aging and Alzheimer's Disease (AD) are needed to combat the expected influx of new AD cases. Until now, the role...
6.
Litberg T, Sannapureddi R, Huang Z, Son A, Sathyamoorthy B, Horowitz S
RNA Biol
. 2023 Jul;
20(1):495-509.
PMID: 37493593
Maintaining a healthy protein folding environment is essential for cellular function. Recently, we found that nucleic acids, G-quadruplexes in particular, are potent chaperones for preventing protein aggregation. With the aid...
7.
Son A, Huizar Cabral V, Huang Z, Litberg T, Horowitz S
Proc Natl Acad Sci U S A
. 2023 May;
120(20):e2216308120.
PMID: 37155907
Maintaining the health of the proteome is a critical cellular task. Recently, we found G-quadruplex (G4) nucleic acids are especially potent at preventing protein aggregation in vitro and could at...
8.
Millstein A, Myers-Coffman K, Horowitz S, Kesslick A, Bradt J
Nord J Music Ther
. 2022 Aug;
30(2):179-191.
PMID: 36035073
Introduction: Treatment manuals play an essential role in clinical trials that aim to determine the efficacy of an intervention. Yet, the idea of needing to adhere to a treatment manual...
9.
Guzman B, Son A, Litberg T, Huang Z, Dominguez D, Horowitz S
FEBS J
. 2022 Aug;
290(19):4614-4625.
PMID: 36017725
How nucleic acids interact with proteins, and how they affect protein folding, aggregation, and misfolding is a still-evolving area of research. Considerable effort is now focusing on a particular structure...
10.
Ahmed J, Fitch T, Donnelly C, Joseph J, Ball T, Bassil M, et al.
Nat Commun
. 2022 Apr;
13(1):2273.
PMID: 35477706
Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there is no successful prevention or intervention. The pathological hallmark for PD involves the self-assembly of functional Alpha-Synuclein (αS) into...