Hashim M Al-Hashimi
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Explore the profile of Hashim M Al-Hashimi including associated specialties, affiliations and a list of published articles.
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164
Citations
4860
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Recent Articles
1.
Manghrani A, Rangadurai A, Szekely O, Liu B, Guseva S, Al-Hashimi H
Biochemistry
. 2025 Feb;
64(5):1042-1054.
PMID: 39982856
The dynamic properties of DNA depend on the sequence, providing an important source of sequence-specificity in biochemical reactions. However, comprehensively measuring how these dynamics vary with sequence is challenging, especially...
2.
Guseva S, Szekely O, Geng A, Smith K, Pratihar S, Gu S, et al.
bioRxiv
. 2025 Jan;
PMID: 39763874
In duplex DNA, A-T and G-C form Watson-Crick base pairs, and Hoogsteen pairing only dominates upon protein binding or DNA damage. Using NMR, we show that an A-T Hoogsteen base...
3.
Geng A, Roy R, Al-Hashimi H
Curr Opin Struct Biol
. 2024 Nov;
89:102949.
PMID: 39522437
The energy cost accompanying changes in the structures of nucleic acids when they bind partner molecules is a significant but underappreciated thermodynamic contribution to binding affinity and specificity. This review...
4.
Bussi G, Bonomi M, Gkeka P, Sattler M, Al-Hashimi H, Auffinger P, et al.
Structure
. 2024 Sep;
32(9):1281-1287.
PMID: 39241758
Conformational dynamics is crucial for the biological function of RNA molecules and for their potential as therapeutic targets. This meeting report outlines key "take-home" messages that emerged from the presentations...
5.
Lee Y, Gu S, Al-Hashimi H
J Mol Biol
. 2024 Jul;
436(18):168710.
PMID: 39009073
Knowing the conformational ensembles formed by mismatches is crucial for understanding how they are generated and repaired and how they contribute to genomic instability. Here, we review structural and energetic...
6.
Roy R, Al-Hashimi H
Nat Struct Mol Biol
. 2024 Jul;
31(7):997-1000.
PMID: 38977902
No abstract available.
7.
Manghrani A, Rangadurai A, Szekely O, Liu B, Guseva S, Al-Hashimi H
bioRxiv
. 2024 May;
PMID: 38798635
The propensities to form lowly-populated short-lived conformations of DNA could vary with sequence, providing an important source of sequence-specificity in biochemical reactions. However, comprehensively measuring how these dynamics vary with...
8.
Gu S, Al-Hashimi H
J Phys Chem B
. 2024 Apr;
128(17):4087-4096.
PMID: 38644782
Elucidating how damage impacts DNA dynamics is essential for understanding the mechanisms of damage recognition and repair. Many DNA lesions alter their propensities to form low-populated and short-lived conformational states....
9.
Gu S, Al-Hashimi H
bioRxiv
. 2024 Jan;
PMID: 38293035
Elucidating how damage impacts DNA dynamics is essential for understanding the mechanisms of damage recognition and repair. Many DNA lesions alter the propensities to form lowly-populated and short-lived conformational states....
10.
Szekely O, Rangadurai A, Gu S, Manghrani A, Guseva S, Al-Hashimi H
Nucleic Acids Res
. 2024 Jan;
52(5):2672-2685.
PMID: 38281263
Many biochemical processes use the Watson-Crick geometry to distinguish correct from incorrect base pairing. However, on rare occasions, mismatches such as G·T/U can transiently adopt Watson-Crick-like conformations through tautomerization or...