James C A Bardwell
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Explore the profile of James C A Bardwell including associated specialties, affiliations and a list of published articles.
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96
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2213
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Recent Articles
1.
Mitra R, Usher E, Dedeoglu S, Crotteau M, Fraser O, Yennawar N, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2409139121.
PMID: 39589885
Intrinsically disordered protein regions (IDRs) are well established as contributors to intermolecular interactions and the formation of biomolecular condensates. In particular, RNA-binding proteins (RBPs) often harbor IDRs in addition to...
2.
Sahoo B, Deng X, Wong E, Clark N, Yang H, Subramanian V, et al.
bioRxiv
. 2024 Nov;
PMID: 39554013
Liquid-liquid phase condensation governs a wide range of protein-protein and protein-RNA interactions in vivo and drives the formation of membrane-less compartments such as the nucleolus and stress granules. We have...
3.
Mitra R, Usher E, Dedeoglu S, Crotteau M, Fraser O, Yennawar N, et al.
bioRxiv
. 2024 Jun;
PMID: 38915483
Intrinsically disordered protein regions (IDRs) are well-established as contributors to intermolecular interactions and the formation of biomolecular condensates. In particular, RNA-binding proteins (RBPs) often harbor IDRs in addition to folded...
4.
Sahoo B, Kocman V, Clark N, Myers N, Deng X, Wong E, et al.
Nucleic Acids Res
. 2024 Apr;
52(8):4702-4722.
PMID: 38572746
The SERF family of proteins were originally discovered for their ability to accelerate amyloid formation. Znf706 is an uncharacterized protein whose N-terminus is homologous to SERF proteins. We show here...
5.
Sahoo B, Subramanian V, Bardwell J
Biomol NMR Assign
. 2024 Mar;
18(1):51-57.
PMID: 38466543
Human small EDRK-rich factor protein SERF2 is a cellular driver of protein amyloid formation, a process that has been linked to neurodegenerative diseases including Alzheimer's and Parkinson's disease. SERF2 is...
6.
Sahoo B, Kocman V, Clark N, Myers N, Deng X, Wong E, et al.
bioRxiv
. 2023 Oct;
PMID: 37790366
The SERF family of proteins were originally discovered for their ability to accelerate amyloid formation. Znf706 is an uncharacterized protein whose N-terminus is homologous to SERF proteins. We show here...
7.
Dulchavsky M, Mitra R, Wu K, Li J, Boer K, Liu X, et al.
Nat Chem Biol
. 2023 Sep;
19(11):1406-1414.
PMID: 37770699
The flavoenzyme nicotine oxidoreductase (NicA2) is a promising injectable treatment to aid in the cessation of smoking, a behavior responsible for one in ten deaths worldwide. NicA2 acts by degrading...
8.
Marcelino T, Ramos Docampo M, Qian X, Ade C, Brodszkij E, Ceccato M, et al.
Macromol Biosci
. 2023 Mar;
23(8):e2200528.
PMID: 36971346
The immobilization of enzymes on solid supports is an important challenge in biotechnology and biomedicine. In contrast to other methods, enzyme deposition in polymer brushes offers the benefit of high...
9.
Bardwell J
Cell
. 2022 Dec;
185(25):4679-4681.
PMID: 36493750
Chaperones are important for protein folding, but visualizing this process has proven to be exceptionally difficult. In this issue of Cell, Frydman and colleagues have succeeded in watching tubulin being...
10.
Ade C, Marcelino T, Dulchavsky M, Wu K, Bardwell J, Stadler B
Mater Adv
. 2022 Oct;
3(8):3649-3662.
PMID: 36238657
Extremophile enzymes are useful in biotechnology and biomedicine due to their abilities to withstand harsh environments. The abilities of histidine ammonia lyases from different extremophiles to preserve their catalytic activities...