Scott B Selleck
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Explore the profile of Scott B Selleck including associated specialties, affiliations and a list of published articles.
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33
Citations
2616
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Recent Articles
1.
Altering heparan sulfate suppresses cell abnormalities and neuron loss in model of Alzheimer Disease
Schultheis N, Connell A, Kapral A, Becker R, Mueller R, Shah S, et al.
iScience
. 2024 Aug;
27(7):110256.
PMID: 39109174
We examined the function of heparan-sulfate-modified proteoglycans (HSPGs) in pathways affecting Alzheimer disease (AD)-related cell pathology in human cell lines and mouse astrocytes. Mechanisms of HSPG influences on dependent cell...
2.
Schultheis N, Connell A, Kapral A, Becker R, Mueller R, Shah S, et al.
bioRxiv
. 2024 Feb;
PMID: 38328107
Mutations in are the most common cause of familial, early-onset Alzheimer's disease (AD), typically producing cognitive deficits in the fourth decade. A variant of , was found associated with protection...
3.
Tillo M, Lamanna W, Dwyer C, Sandoval D, Pessentheiner A, Al-Azzam N, et al.
J Biol Chem
. 2022 Jun;
298(8):102159.
PMID: 35750212
Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy balance associated with cachexia, we assessed the impact of sulfamidase...
4.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
5.
Schultheis N, Jiang M, Selleck S
Matrix Biol
. 2021 Feb;
100-101:173-181.
PMID: 33548399
Autophagy is a fundamental cellular process discovered as a response to nutrient deprivation. It provides the cellular and molecular machinery for catabolism of cellular constituents, generating energy and providing building...
6.
Kim D, Volk H, Girirajan S, Pendergrass S, Hall M, Verma S, et al.
Autism Res
. 2017 Apr;
10(9):1470-1480.
PMID: 28448694
Autism spectrum disorder is a complex trait with a high degree of heritability as well as documented susceptibility from environmental factors. In this study the contributions of copy number variation,...
7.
Reynolds-Peterson C, Zhao N, Xu J, Serman T, Xu J, Selleck S
Autophagy
. 2017 Apr;
13(8):1262-1279.
PMID: 28402693
Heparan sulfate-modified proteoglycans (HSPGs) are important regulators of signaling and molecular recognition at the cell surface and in the extracellular space. Disruption of HSPG core proteins, HS-synthesis, or HS-degradation can...
8.
Ciesielski T, Pendergrass S, White M, Kodaman N, Sobota R, Huang M, et al.
BioData Min
. 2014 Jul;
7:10.
PMID: 25071867
In omic research, such as genome wide association studies, researchers seek to repeat their results in other datasets to reduce false positive findings and thus provide evidence for the existence...
9.
He B, Ludwig M, Dickerson D, Barse L, Arun B, Vilhjalmsson B, et al.
Genetics
. 2013 Nov;
196(2):557-67.
PMID: 24281155
The identification and validation of gene-gene interactions is a major challenge in human studies. Here, we explore an approach for studying epistasis in humans using a Drosophila melanogaster model of...
10.
Lee H, Zhao N, Campion B, Nguyen M, Selleck S
Dev Neurobiol
. 2013 Apr;
73(10):723-43.
PMID: 23592328
The Akt family of serine-threonine kinases integrates a myriad of signals governing cell proliferation, apoptosis, glucose metabolism, and cytoskeletal organization. Akt affects neuronal morphology and function, influencing dendrite growth and...