Thomas P Neufeld
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Explore the profile of Thomas P Neufeld including associated specialties, affiliations and a list of published articles.
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55
Citations
9444
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Recent Articles
1.
Bierlein M, Charles J, Polisuk-Balfour T, Bretscher H, Rice M, Zvonar J, et al.
Genetics
. 2023 Aug;
225(2).
PMID: 37594076
Autophagy, an autophagosome and lysosome-based eukaryotic cellular degradation system, has previously been implicated in lifespan regulation in different animal models. In this report, we show that expression of the RNAi...
2.
Shang L, Aughey E, Kim H, Heden T, Wang L, Najt C, et al.
Aging (Albany NY)
. 2022 Aug;
14(16):6481-6506.
PMID: 36044277
Since interventions such as caloric restriction or fasting robustly promote lipid catabolism and improve aging-related phenotypical markers, we investigated the direct effect of increased lipid catabolism via overexpression of (,...
3.
Klionsky D, Abdel-Aziz A, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, et al.
Autophagy
. 2021 Feb;
17(1):1-382.
PMID: 33634751
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our...
4.
Bjedov I, Cocheme H, Foley A, Wieser D, Woodling N, Castillo-Quan J, et al.
PLoS Genet
. 2020 Nov;
16(11):e1009083.
PMID: 33253201
Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan...
5.
Neufeld T
Dev Cell
. 2020 Mar;
52(5):544-545.
PMID: 32155435
Crosstalk between signaling networks can help coordinate diverse cellular functions. In this issue of Developmental Cell, Tyra et al. identify connections between the cell-growth-promoting transcription factor YAP/Yorkie and the autophagy-regulating...
6.
Pan X, Neufeld T, OConnor M
Curr Biol
. 2019 Aug;
29(17):2840-2851.e4.
PMID: 31422886
Properly timed production of steroid hormones by endocrine tissues regulates juvenile-to-adult transitions in both mammals (puberty) and holometabolous insects (metamorphosis). Nutritional conditions influence the temporal control of the transition, but...
7.
Ayala C, Kim J, Neufeld T
J Cell Sci
. 2018 Aug;
131(17).
PMID: 30111579
The self-degradative process of autophagy is important for energy homeostasis and cytoplasmic renewal. This lysosome-mediated pathway is negatively regulated by the target of rapamycin kinase (TOR) under basal conditions, and...
8.
Kim J, Bilder D, Neufeld T
Genes Dev
. 2018 Feb;
32(2):156-164.
PMID: 29440263
Insulin resistance, the failure to activate insulin signaling in the presence of ligand, leads to metabolic diseases, including type 2 diabetes. Physical activity and mechanical stress have been shown to...
9.
Soreng K, Neufeld T, Simonsen A
Int Rev Cell Mol Biol
. 2018 Feb;
336:1-92.
PMID: 29413888
Macroautophagy is an intracellular pathway used for targeting of cellular components to the lysosome for their degradation and involves sequestration of cytoplasmic material into autophagosomes formed from a double membrane...
10.
Neisch A, Neufeld T, Hays T
J Cell Biol
. 2017 Jan;
216(2):441-461.
PMID: 28100687
Autophagy plays an essential role in the cellular homeostasis of neurons, facilitating the clearance of cellular debris. This clearance process is orchestrated through the assembly, transport, and fusion of autophagosomes...