Scot Marsters
Overview
Explore the profile of Scot Marsters including associated specialties, affiliations and a list of published articles.
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21
Citations
1286
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Recent Articles
1.
Castellano B, Tang D, Marsters S, Lam C, Liu P, Rose C, et al.
Biotechnol Prog
. 2023 May;
39(5):e3354.
PMID: 37161726
During the course of biopharmaceutical production, heterologous protein expression in Chinese hamster ovary (CHO) cells imposes a high proteostatic burden that requires cellular adaptation. To mitigate such burden, cells utilize...
2.
Xi Y, LaCanna R, Ma H, NDiaye E, Gierke S, Caplazi P, et al.
Cell Metab
. 2022 Aug;
34(9):1377-1393.e8.
PMID: 35987202
Fibrosis is the major risk factor associated with morbidity and mortality in patients with non-alcoholic steatohepatitis (NASH)-driven chronic liver disease. Although numerous efforts have been made to identify the mediators...
3.
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Guttman O, Le Thomas A, Marsters S, Lawrence D, Gutgesell L, Zuazo-Gaztelu I, et al.
J Cell Biol
. 2022 Apr;
221(6).
PMID: 35446348
Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based epitopes to CD8+ T cells. DCs process internalized protein antigens into peptides that enter the endoplasmic reticulum (ER), bind to major...
4.
Guidi R, Xu D, Choy D, Ramalingam T, Lee W, Modrusan Z, et al.
Sci Transl Med
. 2022 Apr;
14(641):eabl8146.
PMID: 35442706
Asthma and inflammatory airway diseases restrict airflow in the lung, compromising gas exchange and lung function. Inhaled corticosteroids (ICSs) can reduce inflammation, control symptoms, and improve lung function; however, a...
5.
Cairrao F, Santos C, Le Thomas A, Marsters S, Ashkenazi A, Domingos P
Nat Commun
. 2022 Mar;
13(1):1587.
PMID: 35332141
The unfolded protein response (UPR) maintains homeostasis of the endoplasmic reticulum (ER). Residing in the ER membrane, the UPR mediator Ire1 deploys its cytoplasmic kinase-endoribonuclease domain to activate the key...
6.
Le Thomas A, Ferri E, Marsters S, Harnoss J, Lawrence D, Zuazo-Gaztelu I, et al.
Nat Commun
. 2021 Dec;
12(1):7310.
PMID: 34911951
Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and signals through a cytosolic kinase-endoribonuclease module. The endoribonuclease generates...
7.
Yang Y, Yeh S, Madireddi S, Matochko W, Gu C, Pacheco Sanchez P, et al.
MAbs
. 2019 Jun;
11(6):996-1011.
PMID: 31156033
Agonism of members of the tumor necrosis factor receptor superfamily (TNFRSF) with monoclonal antibodies is of high therapeutic interest due to their role in immune regulation and cell proliferation. A...
8.
Nair P, Ngu H, Torres E, Marsters S, Lawrence D, Stephan J, et al.
Biotechniques
. 2015 Oct;
59(4):231-8, 240.
PMID: 26458551
We developed a strategy for identifying modulators of juxtacrine signaling, triggered by a cell-surface ligand displayed on synthetic lipid bilayers, via cognate receptors on apposed cells. Using readouts for receptor...
9.
Yin Y, Djakovic S, Marsters S, Tien J, Peng J, Tremayne J, et al.
Mol Cancer Ther
. 2015 Aug;
14(10):2270-8.
PMID: 26269606
FGF receptors (FGFR) are attractive candidate targets for cancer therapy because they are dysregulated in several human malignancies. FGFR2 and FGFR3 can be inhibited potentially without disrupting adult tissue homeostasis....
10.
Chen T, Filvaroff E, Peng J, Marsters S, Jubb A, Koeppen H, et al.
EBioMedicine
. 2015 Jul;
2(5):406-20.
PMID: 26137585
Hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) drive cancer through their respective receptors, MET and VEGF receptor 2 (VEGFR2). VEGFR2 inhibits MET by promoting MET dephosphorylation. However,...