Avi Ashkenazi
Overview
Explore the profile of Avi Ashkenazi including associated specialties, affiliations and a list of published articles.
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Articles
132
Citations
7363
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Recent Articles
1.
Acosta-Alvear D, Harnoss J, Walter P, Ashkenazi A
Nat Rev Mol Cell Biol
. 2024 Nov;
26(3):193-212.
PMID: 39501044
Cells rely on the endoplasmic reticulum (ER) to fold and assemble newly synthesized transmembrane and secretory proteins - essential for cellular structure-function and for both intracellular and intercellular communication. To...
2.
Rodvold J, Grimmer M, Ruiz K, Marsters S, Oikonomidi I, Tan-Aristy E, et al.
Cancer Res Commun
. 2024 Sep;
4(10):2734-2755.
PMID: 39324706
ATF6 intervention reduces colorectal cancer cell and organoid viability by interrupting dysregulated Wnt signaling, identifying a novel facilitator and potential therapeutic target in colorectal cancer.
3.
Braun M, Ashkenazi A, Beveridge R, Castanedo G, Wallweber H, Beresini M, et al.
J Med Chem
. 2024 May;
67(11):8708-8729.
PMID: 38748820
The lack of selective and safe in vivo IRE1α tool molecules has limited the evaluation of IRE1α as a viable target to treat multiple myeloma. Focus on improving the physicochemical...
4.
Castellano B, Tang D, Marsters S, Lam C, Liu P, Rose C, et al.
Biotechnol Prog
. 2023 May;
39(5):e3354.
PMID: 37161726
During the course of biopharmaceutical production, heterologous protein expression in Chinese hamster ovary (CHO) cells imposes a high proteostatic burden that requires cellular adaptation. To mitigate such burden, cells utilize...
5.
Xi Y, LaCanna R, Ma H, NDiaye E, Gierke S, Caplazi P, et al.
Cell Metab
. 2022 Aug;
34(9):1377-1393.e8.
PMID: 35987202
Fibrosis is the major risk factor associated with morbidity and mortality in patients with non-alcoholic steatohepatitis (NASH)-driven chronic liver disease. Although numerous efforts have been made to identify the mediators...
6.
Belyy V, Zuazo-Gaztelu I, Alamban A, Ashkenazi A, Walter P
Elife
. 2022 Jun;
11.
PMID: 35730415
Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling network, termed the unfolded protein response (UPR). Inositol-requiring enzyme 1 (IRE1) is an ER membrane-resident kinase/RNase that...
7.
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Guttman O, Le Thomas A, Marsters S, Lawrence D, Gutgesell L, Zuazo-Gaztelu I, et al.
J Cell Biol
. 2022 Apr;
221(6).
PMID: 35446348
Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based epitopes to CD8+ T cells. DCs process internalized protein antigens into peptides that enter the endoplasmic reticulum (ER), bind to major...
8.
Guidi R, Xu D, Choy D, Ramalingam T, Lee W, Modrusan Z, et al.
Sci Transl Med
. 2022 Apr;
14(641):eabl8146.
PMID: 35442706
Asthma and inflammatory airway diseases restrict airflow in the lung, compromising gas exchange and lung function. Inhaled corticosteroids (ICSs) can reduce inflammation, control symptoms, and improve lung function; however, a...
9.
Cairrao F, Santos C, Le Thomas A, Marsters S, Ashkenazi A, Domingos P
Nat Commun
. 2022 Mar;
13(1):1587.
PMID: 35332141
The unfolded protein response (UPR) maintains homeostasis of the endoplasmic reticulum (ER). Residing in the ER membrane, the UPR mediator Ire1 deploys its cytoplasmic kinase-endoribonuclease domain to activate the key...
10.
Le Thomas A, Ferri E, Marsters S, Harnoss J, Lawrence D, Zuazo-Gaztelu I, et al.
Nat Commun
. 2021 Dec;
12(1):7310.
PMID: 34911951
Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER membrane, and signals through a cytosolic kinase-endoribonuclease module. The endoribonuclease generates...