Sandro Alves
Overview
Explore the profile of Sandro Alves including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
4010
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0
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Recent Articles
1.
Audouard E, Khefif N, Gillet-Legrand B, Nobilleau F, Bouazizi O, Stanga S, et al.
Pharmaceutics
. 2024 Jun;
16(6).
PMID: 38931878
Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by mutation in the X-linked gene methyl-CpG-binding protein 2 (Mecp2), a ubiquitously expressed transcriptional regulator. RTT results in mental retardation and...
2.
Piguet F, de Saint Denis T, Audouard E, Beccaria K, Andre A, Wurtz G, et al.
Hum Gene Ther
. 2020 Nov;
32(7-8):349-374.
PMID: 33167739
For more than 10 years, gene therapy for neurological diseases has experienced intensive research growth and more recently therapeutic interventions for multiple indications. Beneficial results in several phase 1/2 clinical...
3.
Nobrega C, Conceicao A, Costa R, Koppenol R, Sequeira R, Nunes R, et al.
BMC Res Notes
. 2020 Apr;
13(1):210.
PMID: 32276655
Objective: Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington's disease (HD). Following our previous studies in HD, in...
4.
Orefice N, Souchet B, Braudeau J, Alves S, Piguet F, Collaud F, et al.
Mol Ther Methods Clin Dev
. 2019 Aug;
14:237-251.
PMID: 31440523
Exosomes represent a strategy for optimizing the adeno-associated virus (AAV) toward the development of novel therapeutic options for neurodegenerative disorders. However, spreading of exosomes and AAVs after intracerebral administration is...
5.
Nobrega C, Mendonca L, Marcelo A, Lamaziere A, Tome S, Despres G, et al.
Acta Neuropathol
. 2019 Jun;
138(5):837-858.
PMID: 31197505
Spinocerebellar ataxias (SCAs) are devastating neurodegenerative disorders for which no curative or preventive therapies are available. Deregulation of brain cholesterol metabolism and impaired brain cholesterol turnover have been associated with...
6.
Souchet B, Audrain M, Billard J, Dairou J, Fol R, Orefice N, et al.
Acta Neuropathol Commun
. 2019 Mar;
7(1):46.
PMID: 30885273
Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer's disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in AD patients...
7.
Marinello M, Werner A, Giannone M, Tahiri K, Alves S, Tesson C, et al.
Dis Model Mech
. 2018 Dec;
12(1).
PMID: 30559154
Perturbation of protein homeostasis and aggregation of misfolded proteins is a major cause of many human diseases. A hallmark of the neurodegenerative disease spinocerebellar ataxia type 7 (SCA7) is the...
8.
9.
Sittler A, Muriel M, Marinello M, Brice A, den Dunnen W, Alves S
Neuropathology
. 2017 Dec;
38(2):113-124.
PMID: 29218765
Autophagy, the major pathway for protein turnover, is critical to maintain cellular homeostasis and has been implicated in neurodegenerative diseases. The aim of this research was to analyze the expression...
10.
Audrain M, Souchet B, Alves S, Fol R, Viode A, Haddjeri A, et al.
Cereb Cortex
. 2017 Oct;
28(11):3976-3993.
PMID: 29048465
The treatment of Alzheimer's disease (AD) remains challenging and requires a better in depth understanding of AD progression. Particularly, the link between amyloid protein precursor (APP) processing and Tau pathology...