Philippe Hantraye
Overview
Explore the profile of Philippe Hantraye including associated specialties, affiliations and a list of published articles.
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Articles
146
Citations
4617
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Recent Articles
1.
de Longprez L, Gaillard M, Decraene C, Perot J, Keime C, Nadkarni N, et al.
Brain
. 2025 Feb;
PMID: 39908340
DCLK3 (Doublecortin-like kinase 3) is a kinase preferentially expressed in neurons. Dclk3 variants are risk factors for psychiatric disorders and brain alterations linked to age-related mild cognitive impairment, suggesting this...
2.
Henriques C, Lopes M, Silva A, Lobo D, Badin R, Hantraye P, et al.
Brain
. 2024 Jan;
147(4):1166-1189.
PMID: 38284949
Polyglutamine disorders are a complex group of incurable neurodegenerative disorders caused by an abnormal expansion in the trinucleotide cytosine-adenine-guanine tract of the affected gene. To better understand these disorders, our...
3.
Duwat C, Leal P, Vautheny A, Auregan G, Josephine C, Gaillard M, et al.
Neurobiol Dis
. 2023 Apr;
181:106116.
PMID: 37054900
Tauopathy is a typical feature of Alzheimer's disease of major importance because it strongly correlates with the severity of cognitive deficits experienced by patients. During the pathology, it follows a...
4.
Fayard A, Fenyi A, Lavisse S, Dovero S, Bousset L, Bellande T, et al.
Neurobiol Dis
. 2023 Mar;
180:106086.
PMID: 36933673
The role of alpha-synuclein in Parkinson's disease has been heavily investigated since its discovery as a component of Lewy bodies. Recent rodent data demonstrate that alpha-synuclein strain structure is critical...
5.
Abjean L, Ben Haim L, Riquelme-Perez M, Gipchtein P, Derbois C, Palomares M, et al.
Brain
. 2022 Mar;
146(1):149-166.
PMID: 35298632
Huntington's disease is a fatal neurodegenerative disease characterized by striatal neurodegeneration, aggregation of mutant Huntingtin and the presence of reactive astrocytes. Astrocytes are important partners for neurons and engage in...
6.
Cresto N, Gardier C, Gaillard M, Gubinelli F, Roost P, Molina D, et al.
Int J Mol Sci
. 2021 Jul;
22(13).
PMID: 34201785
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that...
7.
Vautheny A, Duwat C, Auregan G, Josephine C, Herard A, Jan C, et al.
Neurobiol Dis
. 2021 May;
155:105398.
PMID: 34019997
The role played by microglia has taken the center of the stage in the etiology of Alzheimer's disease (AD). Several genome-wide association studies carried out on large cohorts of patients...
8.
Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state
Mate de Gerando A, dOrange M, Augustin E, Josephine C, Auregan G, Gaudin-Guerif M, et al.
Brain
. 2021 Apr;
144(4):1167-1182.
PMID: 33842937
Deposits of different abnormal forms of tau in neurons and astrocytes represent key anatomo-pathological features of tauopathies. Although tau protein is highly enriched in neurons and poorly expressed by astrocytes,...
9.
Goutal S, Guillermier M, Becker G, Gaudin M, Bramoulle Y, Luxen A, et al.
EJNMMI Res
. 2021 Apr;
11(1):36.
PMID: 33826008
Background: Positron Emission Tomography (PET) imaging of the Synaptic Vesicle glycoprotein (SV) 2A is a new tool to quantify synaptic density. [F]UCB-H was one of the first promising SV2A-ligands to...
10.
Gauvain G, Akolkar H, Chaffiol A, Arcizet F, Khoei M, Desrosiers M, et al.
Commun Biol
. 2021 Jan;
4(1):125.
PMID: 33504896
Vision restoration is an ideal medical application for optogenetics, because the eye provides direct optical access to the retina for stimulation. Optogenetic therapy could be used for diseases involving photoreceptor...