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Nathalie Cartier

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Articles 56
Citations 3110
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Recent Articles
1.
Audouard E, Khefif N, Gillet-Legrand B, Nobilleau F, Bouazizi O, Stanga S, et al.
Pharmaceutics . 2024 Jun; 16(6). PMID: 38931878
Rett syndrome (RTT) is a rare neurodevelopmental disorder caused by mutation in the X-linked gene methyl-CpG-binding protein 2 (Mecp2), a ubiquitously expressed transcriptional regulator. RTT results in mental retardation and...
2.
Nunes M, Carvalho A, Reis J, Costa D, Moutinho M, Mateus J, et al.
Biochim Biophys Acta Mol Basis Dis . 2023 Dec; 1870(3):166993. PMID: 38142760
Cholesterol 24-hydroxylase (CYP46A1) is an exclusively neuronal cytochrome P450 enzyme responsible for converting cholesterol into 24S-hydroxycholesterol, which serves as the primary pathway for eliminating cholesterol in the brain. We and...
3.
Rosenberg J, Fung E, Dyke J, De B, Lou H, Kelly J, et al.
Hum Gene Ther . 2023 Aug; 34(21-22):1095-1106. PMID: 37624734
Based on studies in experimental animals demonstrating that administration of adeno-associated virus (AAV) vectors to the cerebrospinal fluid (CSF) is an effective route to transfer genes to the nervous system,...
4.
Audouard E, Michel F, Pierroz V, Kim T, Rousselot L, Gillet-Legrand B, et al.
J Control Release . 2022 Nov; 352:994-1008. PMID: 36370877
Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled...
5.
Aigrot M, Barthelemy C, Moyon S, Dufayet-Chaffaud G, Izagirre-Urizar L, Gillet-Legrand B, et al.
EMBO Mol Med . 2022 Jul; 14(8):e14759. PMID: 35822550
Preventing neurodegeneration-associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this process in patients might enhance neuroprotection. In demyelinating...
6.
Sailor K, Agoranos G, Lopez-Manzaneda S, Tada S, Gillet-Legrand B, Guerinot C, et al.
Nat Med . 2022 Feb; 28(3):517-527. PMID: 35190726
Hematopoietic stem cell transplantation (HSCT) is a therapy used for multiple malignant and nonmalignant diseases, with chemotherapy used for pretransplantation myeloablation. The post-HSCT brain contains peripheral engrafted parenchymal macrophages, despite...
7.
Pikuleva I, Cartier N
Front Aging Neurosci . 2021 Jul; 13:696778. PMID: 34305573
Cholesterol, an essential component of the brain, and its local metabolism are involved in many neurodegenerative diseases. The blood-brain barrier is impermeable to cholesterol; hence, cholesterol homeostasis in the central...
8.
Audouard E, Rousselot L, Folcher M, Cartier N, Piguet F
Front Bioeng Biotechnol . 2021 Jul; 9:620967. PMID: 34249877
Improving a drug delivery system is critical to treat central nervous system disorders. Here we studied an innovative approach based on implantation of a wireless-powered cell-based device in mice. This...
9.
Audouard E, Oger V, Meha B, Cartier N, Sevin C, Piguet F
Front Mol Neurosci . 2021 Jun; 14:677895. PMID: 34093126
Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder characterized by accumulation of sulfatides in both glial cells and neurons. MLD results from an inherited deficiency of arylsulfatase A (ARSA) and...
10.
Piguet F, de Saint Denis T, Audouard E, Beccaria K, Andre A, Wurtz G, et al.
Hum Gene Ther . 2020 Nov; 32(7-8):349-374. PMID: 33167739
For more than 10 years, gene therapy for neurological diseases has experienced intensive research growth and more recently therapeutic interventions for multiple indications. Beneficial results in several phase 1/2 clinical...