Sandhya Sanduja
Overview
Explore the profile of Sandhya Sanduja including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
784
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0
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Recent Articles
1.
Sanduja S, Lessey-Morillon L, Allen R, Wang X, Imperato G, Arcidiacono J
Adv Exp Med Biol
. 2023 Aug;
1430:71-89.
PMID: 37526843
Research and development of gene therapies and cell- or tissue-based therapies has experienced exponential growth in recent decades and the potential for these products to treat diverse, often rare, clinical...
2.
Sokol E, Feng Y, Jin D, Tizabi M, Miller D, Cohen M, et al.
Proc Natl Acad Sci U S A
. 2017 Apr;
114(16):4153-4158.
PMID: 28377514
Advances in mammography have sparked an exponential increase in the detection of early-stage breast lesions, most commonly ductal carcinoma in situ (DCIS). More than 50% of DCIS lesions are benign...
3.
Sobolewski C, Sanduja S, Blanco F, Hu L, Dixon D
Biomolecules
. 2015 Sep;
5(3):2035-55.
PMID: 26343742
The RNA-binding protein tristetraprolin (TTP) promotes rapid decay of mRNAs bearing 3' UTR AU-rich elements (ARE). In many cancer types, loss of TTP expression is observed allowing for stabilization of...
4.
Sokol E, Sanduja S, Jin D, Miller D, Mathis R, Gupta P
PLoS Comput Biol
. 2015 Apr;
11(4):e1004161.
PMID: 25894653
The search for genes that regulate stem cell self-renewal and differentiation has been hindered by a paucity of markers that uniquely label stem cells and early progenitors. To circumvent this...
5.
Del Vecchio C, Feng Y, Sokol E, Tillman E, Sanduja S, Reinhardt F, et al.
PLoS Biol
. 2014 Sep;
12(9):e1001945.
PMID: 25203443
Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)-scavenging enzymes and drug efflux pumps, but...
6.
Feng Y, Sokol E, Del Vecchio C, Sanduja S, Claessen J, Proia T, et al.
Cancer Discov
. 2014 Apr;
4(6):702-15.
PMID: 24705811
Unlabelled: Epithelial-to-mesenchymal transition (EMT) promotes both tumor progression and drug resistance, yet few vulnerabilities of this state have been identified. Using selective small molecules as cellular probes, we show that...
7.
Blanco F, Sanduja S, Deane N, Blackshear P, Dixon D
Mol Cell Biol
. 2013 Nov;
34(2):180-95.
PMID: 24190969
Transforming growth factor β (TGF-β) is a potent growth regulator and tumor suppressor in normal intestinal epithelium. Likewise, epithelial cell growth is controlled by rapid decay of growth-related mRNAs mediated...
8.
Upadhyay R, Sanduja S, Kaza V, Dixon D
Int J Cancer
. 2012 Aug;
132(3):E128-38.
PMID: 22907529
The RNA-binding proteins TTP and HuR control expression of numerous genes associated with breast cancer pathogenesis by regulating mRNA stability. However, the role of genetic variation in TTP (ZFP36) and...
9.
Rounbehler R, Fallahi M, Yang C, Steeves M, Li W, Doherty J, et al.
Cell
. 2012 Aug;
150(3):563-74.
PMID: 22863009
Myc oncoproteins directly regulate transcription by binding to target genes, yet this only explains a fraction of the genes affected by Myc. mRNA turnover is controlled via AU-binding proteins (AUBPs)...
10.
Sanduja S, Blanco F, Young L, Kaza V, Dixon D
Front Biosci (Landmark Ed)
. 2011 Dec;
17(1):174-88.
PMID: 22201737
Messenger RNA decay is a critical mechanism to control the expression of many inflammation- and cancer-associated genes. These transcripts are targeted for rapid degradation through AU-rich element (ARE) motifs present...