SMARCE1 is Required for the Invasive Progression of in Situ Cancers

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2017 Apr 6

PMID 28377514

Citations 24

Authors

Ethan S Sokol

Yu-Xiong Feng

Dexter X Jin

Minu D Tizabi

Daniel H Miller

Malkiel A Cohen

Sandhya Sanduja

Ferenc Reinhardt

Jai Pandey

Daphne A Superville

Rudolf Jaenisch

Piyush B Gupta

Affiliations

Soon will be listed here.

Abstract

Advances in mammography have sparked an exponential increase in the detection of early-stage breast lesions, most commonly ductal carcinoma in situ (DCIS). More than 50% of DCIS lesions are benign and will remain indolent, never progressing to invasive cancers. However, the factors that promote DCIS invasion remain poorly understood. Here, we show that SMARCE1 is required for the invasive progression of DCIS and other early-stage tumors. We show that SMARCE1 drives invasion by regulating the expression of secreted proteases that degrade basement membrane, an ECM barrier surrounding all epithelial tissues. In functional studies, SMARCE1 promotes invasion of in situ cancers growing within primary human mammary tissues and is also required for metastasis in vivo. Mechanistically, SMARCE1 drives invasion by forming a SWI/SNF-independent complex with the transcription factor ILF3. In patients diagnosed with early-stage cancers, SMARCE1 expression is a strong predictor of eventual relapse and metastasis. Collectively, these findings establish SMARCE1 as a key driver of invasive progression in early-stage tumors.

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