Samuel G Mackintosh
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Explore the profile of Samuel G Mackintosh including associated specialties, affiliations and a list of published articles.
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81
Citations
2035
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Recent Articles
1.
Hardman-Kavanaugh R, Storey A, Stuecker T, Hood S, Barrett-Wilt G, Krishnamurthi V, et al.
bioRxiv
. 2025 Feb;
PMID: 39935887
All organisms experience stress and must rapidly respond to changing conditions. Thus, cells have evolved sophisticated rapid-response mechanisms such as post-translational protein modification to rapidly and reversibly modulate protein activity....
2.
Ahn J, Guo Y, Lyons H, Mackintosh S, Lau B, Edmondson R, et al.
Mol Cell
. 2025 Feb;
85(4):708-725.e9.
PMID: 39922194
Recurrent cancer-causing fusions of NUP98 produce higher-order assemblies known as condensates. How NUP98 oncofusion-driven condensates activate oncogenes remains poorly understood. Here, we investigate NUP98-PHF23, a leukemogenic chimera of the disordered...
3.
Beenken K, Campbell M, Byrum S, Edmondson R, Mackintosh S, Tackett A, et al.
Microorganisms
. 2025 Jan;
13(1).
PMID: 39858949
Using a murine osteomyelitis model, we recently demonstrated that and mutants generated in the USA300 strain LAC are attenuated to a greater extent than an isogenic mutant and that this...
4.
Martinez Barrera S, Hatchell E, Byrum S, Mackintosh S, Kozubowski L
PLoS One
. 2024 Dec;
19(12):e0313444.
PMID: 39689097
Cryptococcus neoformans is a pathogenic basidiomycetous yeast that primarily infects immunocompromised individuals. Fatal outcome of cryptococcosis depends on the ability of C. neoformans to sense and adapt to 37°C. A...
5.
Bolin E, Mourani P, Byrum S, Mackintosh S, Dossey A, Angtuaco M, et al.
Pediatr Res
. 2024 Aug;
PMID: 39134758
Approximately 1000 children are born every year in the United States with one effective cardiac pumping chamber, or single ventricle heart disease. One of the early causes of mortality in...
6.
Daneshgar N, Lan R, Regnier M, Mackintosh S, Venkatasubramanian R, Dai D
Geroscience
. 2024 Jul;
46(5):4729-4741.
PMID: 38976132
Aging leads to a progressive decline in cardiac function, increasing the risk of heart failure with preserved ejection fraction (HFpEF). This study elucidates the impact of α-Klotho, an anti-aging hormone,...
7.
Espejo-Serrano C, Aitken C, Tan B, May D, Chrisopulos R, Roux K, et al.
Life Sci Alliance
. 2024 Jan;
7(3).
PMID: 38199845
Protein ubiquitylation regulates key biological processes including transcription. This is exemplified by the E3 ubiquitin ligase RNF12/RLIM, which controls developmental gene expression by ubiquitylating the REX1 transcription factor and is...
8.
Zhao S, Lu J, Pan B, Fan H, Byrum S, Xu C, et al.
Nature
. 2023 Nov;
623(7987):633-642.
PMID: 37938770
Trimethylation of histone H3 lysine 9 (H3K9me3) is crucial for the regulation of gene repression and heterochromatin formation, cell-fate determination and organismal development. H3K9me3 also provides an essential mechanism for...
9.
Hashimi M, Sebrell T, Hedges J, Snyder D, Lyon K, Byrum S, et al.
Nat Commun
. 2023 Oct;
14(1):6882.
PMID: 37898615
Bats are natural reservoirs for several zoonotic viruses, potentially due to an enhanced capacity to control viral infection. However, the mechanisms of antiviral responses in bats are poorly defined. Here...
10.
Garg S, Morehead L, Bird J, Graw S, Gies A, Storey A, et al.
Mol Omics
. 2023 Oct;
20(1):37-47.
PMID: 37782107
Dietary methionine restriction is associated with a reduction in tumor growth in preclinical studies and an increase in lifespan in animal models. The mechanism by which methionine restriction inhibits tumor...