Alan J Tackett
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Explore the profile of Alan J Tackett including associated specialties, affiliations and a list of published articles.
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145
Citations
4829
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Recent Articles
1.
Hardman-Kavanaugh R, Storey A, Stuecker T, Hood S, Barrett-Wilt G, Krishnamurthi V, et al.
bioRxiv
. 2025 Feb;
PMID: 39935887
All organisms experience stress and must rapidly respond to changing conditions. Thus, cells have evolved sophisticated rapid-response mechanisms such as post-translational protein modification to rapidly and reversibly modulate protein activity....
2.
Ahn J, Guo Y, Lyons H, Mackintosh S, Lau B, Edmondson R, et al.
Mol Cell
. 2025 Feb;
85(4):708-725.e9.
PMID: 39922194
Recurrent cancer-causing fusions of NUP98 produce higher-order assemblies known as condensates. How NUP98 oncofusion-driven condensates activate oncogenes remains poorly understood. Here, we investigate NUP98-PHF23, a leukemogenic chimera of the disordered...
3.
Beenken K, Campbell M, Byrum S, Edmondson R, Mackintosh S, Tackett A, et al.
Microorganisms
. 2025 Jan;
13(1).
PMID: 39858949
Using a murine osteomyelitis model, we recently demonstrated that and mutants generated in the USA300 strain LAC are attenuated to a greater extent than an isogenic mutant and that this...
4.
Hong A, Piva M, Liu S, Hugo W, Lomeli S, Zoete V, et al.
Cancer Discov
. 2024 Jul;
14(7):1357.
PMID: 38946326
No abstract available.
5.
Urbaniak A, Bathula C, Chauhan J, Rai P, Thammathong J, Clark C, et al.
Chem Biodivers
. 2023 Nov;
20(12):e202301550.
PMID: 37994208
A major challenge for clinical management of melanoma is the prevention and treatment of metastatic disease. Drug discovery efforts over the last 10 years have resulted in several drugs that...
6.
Zhao S, Lu J, Pan B, Fan H, Byrum S, Xu C, et al.
Nature
. 2023 Nov;
623(7987):633-642.
PMID: 37938770
Trimethylation of histone H3 lysine 9 (H3K9me3) is crucial for the regulation of gene repression and heterochromatin formation, cell-fate determination and organismal development. H3K9me3 also provides an essential mechanism for...
7.
Morehead L, Koss B, Fil D, Heflin B, Garg S, Wallis K, et al.
Mol Immunol
. 2023 Oct;
163:188-195.
PMID: 37837954
Immune checkpoint inhibitor therapy has drastically improved outcomes in treating cancer, particularly in melanoma. However, half of melanoma patients are resistant to treatment. One mechanism used by tumor cells to...
8.
Garg S, Morehead L, Bird J, Graw S, Gies A, Storey A, et al.
Mol Omics
. 2023 Oct;
20(1):37-47.
PMID: 37782107
Dietary methionine restriction is associated with a reduction in tumor growth in preclinical studies and an increase in lifespan in animal models. The mechanism by which methionine restriction inhibits tumor...
9.
Morehead L, Garg S, Wallis K, Simoes C, Siegel E, Tackett A, et al.
Cancers (Basel)
. 2023 Sep;
15(18).
PMID: 37760436
Dietary methionine restriction (MR), defined as a reduction of methionine intake by around 80%, has been shown to reproducibly decrease tumor growth and synergize with cancer therapies. In this study,...
10.
Alam J, Huda M, Tackett A, Miah S
Cancer Metastasis Rev
. 2023 May;
42(2):409-425.
PMID: 37147457
Signaling pathways play critical roles in executing and controlling important biological processes within cells. Cells/organisms trigger appropriate signal transduction pathways in order to turn on or off intracellular gene expression...