Samuel G Mackintosh
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Explore the profile of Samuel G Mackintosh including associated specialties, affiliations and a list of published articles.
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81
Citations
2035
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Recent Articles
11.
Todorova V, Byrum S, Mackintosh S, Jamshidi-Parsian A, Gies A, Washam C, et al.
Int J Mol Sci
. 2023 Sep;
24(17).
PMID: 37685904
Infection with hepatitis B virus (HBV) is a main risk factor for hepatocellular carcinoma (HCC). Extracellular vesicles, such as exosomes, play an important role in tumor development and metastasis, including...
12.
Seman A, Chandra P, Byrum S, Mackintosh S, Gies A, Busija D, et al.
Geroscience
. 2023 Jul;
45(5):2951-2965.
PMID: 37458933
Cognitive impairment and dementias during aging such as Alzheimer's disease are linked to functional decline and structural alterations of the brain microvasculature. Although mechanisms leading to microvascular changes during aging...
13.
Chen M, Li J, Zhang L, Wang L, Cheng C, Ji H, et al.
Nucleic Acids Res
. 2023 Jun;
51(14):7288-7313.
PMID: 37378433
We have conducted a detailed transcriptomic, proteomic and phosphoproteomic analysis of CDK8 and its paralog CDK19, alternative enzymatic components of the kinase module associated with transcriptional Mediator complex and implicated...
14.
Garg S, Morehead L, Bird J, Graw S, Gies A, Storey A, et al.
bioRxiv
. 2023 Apr;
PMID: 37066392
Dietary methionine restriction is associated with a reduction in tumor growth in preclinical studies and an increase in lifespan in animal models. The mechanism by which methionine restriction inhibits tumor...
15.
Pei J, Xiao Y, Liu X, Hu W, Sobh A, Yuan Y, et al.
Cell Chem Biol
. 2023 Feb;
30(2):203-213.e17.
PMID: 36750097
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that degrade target proteins through recruiting E3 ligases. However, their application is limited in part because few E3 ligases can be recruited by...
16.
Hashimi M, Sebrell T, Hedges J, Snyder D, Lyon K, Byrum S, et al.
Res Sq
. 2022 Dec;
PMID: 36561186
Bats are natural reservoirs for several zoonotic viruses, potentially due to an enhanced capacity to control viral infection. However, the mechanisms of antiviral responses in bats are poorly defined. Here...
17.
Chau M, Quintero J, Blalock E, Byrum S, Mackintosh S, Samaan C, et al.
PLoS One
. 2022 Nov;
17(11):e0260998.
PMID: 36417411
Regeneration after severe peripheral nerve injury is often poor. Knowledge of human nerve regeneration and the growth microenvironment is greatly lacking. We aimed to identify the regenerative proteins in human...
18.
Scieszka D, Byrum S, Mackintosh S, Madison M, Knight J, Campen M, et al.
Am J Respir Cell Mol Biol
. 2022 Sep;
67(4):503-506.
PMID: 36178855
No abstract available.
19.
Das B, Wang L, Fujiwara T, Zhou J, Aykin-Burns N, Krager K, et al.
Elife
. 2022 Jun;
11.
PMID: 35758636
Increased intracellular iron spurs mitochondrial biogenesis and respiration to satisfy high-energy demand during osteoclast differentiation and bone-resorbing activities. Transferrin receptor 1 (Tfr1) mediates cellular iron uptake through endocytosis of iron-loaded...
20.
Li D, Yu X, Kottur J, Gong W, Zhang Z, Storey A, et al.
Oncogene
. 2022 May;
41(24):3328-3340.
PMID: 35525905
WD repeat domain 5 (WDR5), an integral component of the MLL/KMT2A lysine methyltransferase complex, is critically involved in oncogenesis and represents an attractive onco-target. Inhibitors targeting protein-protein interactions (PPIs) between...