Sai-Yang Zhang
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Explore the profile of Sai-Yang Zhang including associated specialties, affiliations and a list of published articles.
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Articles
60
Citations
384
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Recent Articles
1.
Liu Y, Wang Z, Du Y, Liu X, Niu J, Song J, et al.
Bioorg Med Chem
. 2025 Feb;
121:118109.
PMID: 39955801
Protein kinases represent a highly promising drug target, with over 80 drugs that target about two dozen different protein kinases have been approved by the US FDA, particularly in cancer...
2.
Wang X, Li Y, Wu J, Niu J, Song J, Zhang S
Eur J Med Chem
. 2025 Feb;
287:117328.
PMID: 39947050
In this work, we report the discovery of 2,4-diaminopyrimidine derivatives bearing a urea moiety as FAK inhibitors capable of activating the Hippo pathway in Esophageal Squamous Cell Carcinoma (ESCC). Extensive...
3.
Liu W, Yang W, Wu J, Chen B, Du Y, Niu J, et al.
Eur J Med Chem
. 2025 Jan;
286:117314.
PMID: 39874633
Based on the molecular hybridization strategy, novel thienopyridine indole derivatives were designed and synthesized as tubulin polymerization inhibitors, and the in vitro antiproliferative potency on MGC-803, KYSE450 and HCT-116 cells...
4.
5.
Li H, Jia M, Qin Z, Lu C, Chu W, Zhang Z, et al.
J Enzyme Inhib Med Chem
. 2024 Nov;
39(1):2423875.
PMID: 39560175
In this work, thirty 2,4-diarylaminopyrimidine-based hydrazones were designed, synthesised, and their anti-thyroid cancer activity were explored. The majority of compounds exhibit moderate to excellent cytotoxic activity against FAK overexpressing TPC-1...
6.
Fu X, Huang J, Li N, Liu Y, Liu Q, Yuan S, et al.
Eur J Med Chem
. 2024 Nov;
262:115883.
PMID: 39491429
In this work, we utilized the N-benzylaryl derivative 9 as a lead compound and employed the molecular hybridization strategy by introducing cinnamoyl fragments to successfully design and synthesize 33 novel...
7.
Fu X, Li N, Wu J, Wang Z, Liu R, Niu J, et al.
Eur J Med Chem
. 2024 Aug;
277:116761.
PMID: 39151276
The P-glycoprotein (ABCB1)-mediated multidrug resistance (MDR) has emerged as a significant impediment to the efficacy of cancer chemotherapy in clinical therapy, which could promote the development of effective agents for...
8.
Li N, Liu Y, Wu J, Liu Q, Niu J, Zhang Y, et al.
Eur J Med Chem
. 2024 Jul;
276:116694.
PMID: 39047607
As a highly conserved signaling network across different species, the Hippo pathway is involved in various biological processes. Dysregulation of the Hippo pathway could lead to a wide range of...
9.
Wang X, Li N, Liu Y, Wu J, Liu Q, Niu J, et al.
Eur J Med Chem
. 2024 Jul;
276:116678.
PMID: 39029337
Focal adhesion kinase (FAK) is considered as a pivotal intracellular non-receptor tyrosine kinase, and has garnered significant attention as a promising target for anticancer drug development. As of early 2024,...
10.
Yang R, Fu X, Fan J, Wang T, Song J, Xu T, et al.
Bioorg Med Chem
. 2024 May;
107:117762.
PMID: 38759254
Honokiol, derived from Magnolia officinalis (a traditional Chinese medicine), has been reported to have anticancer activity. Here, a series of novel honokiol thioethers bearing a 1,3,4-oxadiazole moiety were prepared and...