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S J Froelich-Ammon

Explore the profile of S J Froelich-Ammon including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 300
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Recent Articles
1.
Froelich-Ammon S, Kingma P, Osheroff N
Methods Mol Biol . 2003 Jul; 94:199-212. PMID: 12844876
No abstract available.
2.
Burden D, Froelich-Ammon S, Osheroff N
Methods Mol Biol . 2000 Nov; 95:283-9. PMID: 11089240
No abstract available.
3.
Shapiro P, Whalen A, Tolwinski N, Wilsbacher J, Froelich-Ammon S, Garcia M, et al.
Mol Cell Biol . 1999 Apr; 19(5):3551-60. PMID: 10207078
The mitogen-activated protein (MAP) kinases, extracellular signal-related kinase 1 (ERK1) and ERK2, regulate cellular responses by mediating extracellular growth signals toward cytoplasmic and nuclear targets. A potential target for ERK...
4.
Froelich-Ammon S, Dickinson B, Bevilacqua J, SCHULTZ S, Cech T
Genes Dev . 1998 May; 12(10):1504-14. PMID: 9585510
Telomere proteins protect the chromosomal terminus from nucleolytic degradation and end-to-end fusion, and they may contribute to telomere length control and the regulation of telomerase. The current studies investigate the...
5.
Burden D, Kingma P, Froelich-Ammon S, Bjornsti M, Patchan M, Thompson R, et al.
J Biol Chem . 1996 Nov; 271(46):29238-44. PMID: 8910583
Topoisomerase II is the target for several highly active anticancer drugs that induce cell death by enhancing enzyme-mediated DNA scission. Although these agents dramatically increase levels of nucleic acid cleavage...
6.
Froelich-Ammon S, Burden D, Patchan M, Elsea S, Thompson R, Osheroff N
J Biol Chem . 1995 Nov; 270(47):28018-21. PMID: 7499285
Altered sensitivity of topoisomerase II to anticancer drugs profoundly affects the response of eukaryotic cells to these agents. Therefore, several approaches were employed to elucidate the mechanism of drug hypersensitivity...
7.
Froelich-Ammon S, Osheroff N
J Biol Chem . 1995 Sep; 270(37):21429-32. PMID: 7665550
No abstract available.
8.
Froelich-Ammon S, Patchan M, Osheroff N, Thompson R
J Biol Chem . 1995 Jun; 270(25):14998-5004. PMID: 7797481
Although a number of drugs currently in use for the treatment of human cancers act by stimulating topoisomerase II-mediated DNA breakage, little is known regarding interactions between these agents and...
9.
Froelich-Ammon S, Gale K, Osheroff N
J Biol Chem . 1994 Mar; 269(10):7719-25. PMID: 8125998
To further define the nucleic acid determinants that govern the recognition of DNA by topoisomerase II, the ability of the enzyme to cleave a 51-base oligonucleotide that contained a centrally...
10.
Froelich-Ammon S, McGuirk P, Gootz T, Jefson M, Osheroff N
Antimicrob Agents Chemother . 1993 Apr; 37(4):646-51. PMID: 8388196
A series of novel C-7 quinolyl-substituted enantiomers of ofloxacin were used to determine the stereospecificity of topoisomerase II for the C-11 methyl group in tricyclic quinolones. In all cases, the...