S A Lira
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Explore the profile of S A Lira including associated specialties, affiliations and a list of published articles.
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50
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2900
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Recent Articles
1.
Roulis M, Bongers G, Armaka M, Salviano T, He Z, Singh A, et al.
Mucosal Immunol
. 2015 Oct;
9(3):787-97.
PMID: 26487367
Deregulation of host-microbiota interactions in the gut is a pivotal characteristic of Crohn's disease. It remains unclear, however, whether commensals and/or the dysbiotic microbiota associated with pathology in humans are...
2.
Elson C, Chang E, Lira S
Mucosal Immunol
. 2014 Feb;
7(2):205-9.
PMID: 24553067
No abstract available.
3.
TNFα-dependent development of lymphoid tissue in the absence of RORγt⁺ lymphoid tissue inducer cells
Furtado G, Pacer M, Bongers G, Benezech C, He Z, Chen L, et al.
Mucosal Immunol
. 2013 Oct;
7(3):602-14.
PMID: 24129162
Lymphoid tissue often forms within sites of chronic inflammation. Here we report that expression of the proinflammatory cytokine tumor necrosis factor α (TNFα) drives development of lymphoid tissue in the...
4.
Viejo-Borbolla A, Martin A, Muniz L, Shang L, Marchesi F, Thirunarayanan N, et al.
Mucosal Immunol
. 2010 Jul;
3(6):633-44.
PMID: 20664576
Tumor necrosis factor α (TNFα) is a key pathogenic factor in Crohn's disease and rheumatoid arthritis. TNF(ΔARE) mice express high levels of TNFα and present Crohn's-like ileitis and arthritis. Alterations...
5.
Marchesi F, Martin A, Thirunarayanan N, Devany E, Mayer L, Grisotto M, et al.
Mucosal Immunol
. 2009 Sep;
2(6):486-94.
PMID: 19741597
The chemokine CXCL13 is overexpressed in the intestine during inflammation. To mimic this condition, we created transgenic mice-expressing CXCL13 in intestinal epithelial cells. CXCL13 expression promoted a marked increase in...
6.
Holst P, Rosenkilde M, Manfra D, Chen S, Wiekowski M, Holst B, et al.
J Clin Invest
. 2001 Dec;
108(12):1789-96.
PMID: 11748262
ORF74 (or KSHV-vGPCR) is a highly constitutively active G protein-coupled receptor encoded by HHV8 that is regulated both positively and negatively by endogenous chemokines. When expressed in transgenic mice, this...
7.
Wiekowski M, Chen S, Zalamea P, Wilburn B, Kinsley D, Sharif W, et al.
J Immunol
. 2001 Dec;
167(12):7102-10.
PMID: 11739532
We developed transgenic mice conditionally expressing the neutrophil chemoattracting chemokine KC and the beta-galactosidase gene in multiple tissues. In these transgenic mice, doxycycline treatment induced a strong up-regulation in the...
8.
Lukacs N, Prosser D, Wiekowski M, Lira S, Cook D
J Exp Med
. 2001 Aug;
194(4):551-5.
PMID: 11514610
Allergic asthmatic responses in the airway are associated with airway hyperreactivity, eosinophil accumulation in the lung, and cytokine production by allergen-specific, T helper cell type 2 (Th2) lymphocytes. Here, we...
9.
Foster C, Prosser D, Agans J, Zhai Y, Smith M, Lachowicz J, et al.
J Clin Invest
. 2001 Jun;
107(12):1591-8.
PMID: 11413167
ADP plays a critical role in modulating thrombosis and hemostasis. ADP initiates platelet aggregation by simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12. Activation of P2Y1 activates phospholipase...
10.
Wiekowski M, Leach M, Evans E, Sullivan L, Chen S, Vassileva G, et al.
J Immunol
. 2001 Jun;
166(12):7563-70.
PMID: 11390512
p19, a molecule structurally related to IL-6, G-CSF, and the p35 subunit of IL-12, is a subunit of the recently discovered cytokine IL-23. Here we show that expression of p19...