M T Wiekowski
Overview
Explore the profile of M T Wiekowski including associated specialties, affiliations and a list of published articles.
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9
Citations
639
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Recent Articles
1.
Holst P, Rosenkilde M, Manfra D, Chen S, Wiekowski M, Holst B, et al.
J Clin Invest
. 2001 Dec;
108(12):1789-96.
PMID: 11748262
ORF74 (or KSHV-vGPCR) is a highly constitutively active G protein-coupled receptor encoded by HHV8 that is regulated both positively and negatively by endogenous chemokines. When expressed in transgenic mice, this...
2.
Wiekowski M, Chen S, Zalamea P, Wilburn B, Kinsley D, Sharif W, et al.
J Immunol
. 2001 Dec;
167(12):7102-10.
PMID: 11739532
We developed transgenic mice conditionally expressing the neutrophil chemoattracting chemokine KC and the beta-galactosidase gene in multiple tissues. In these transgenic mice, doxycycline treatment induced a strong up-regulation in the...
3.
Foster C, Prosser D, Agans J, Zhai Y, Smith M, Lachowicz J, et al.
J Clin Invest
. 2001 Jun;
107(12):1591-8.
PMID: 11413167
ADP plays a critical role in modulating thrombosis and hemostasis. ADP initiates platelet aggregation by simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12. Activation of P2Y1 activates phospholipase...
4.
Wiekowski M, Leach M, Evans E, Sullivan L, Chen S, Vassileva G, et al.
J Immunol
. 2001 Jun;
166(12):7563-70.
PMID: 11390512
p19, a molecule structurally related to IL-6, G-CSF, and the p35 subunit of IL-12, is a subunit of the recently discovered cytokine IL-23. Here we show that expression of p19...
5.
Cook D, Chen S, Sullivan L, Manfra D, Wiekowski M, Prosser D, et al.
Mol Cell Biol
. 2001 Apr;
21(9):3159-65.
PMID: 11287620
Fractalkine (CX(3)CL1) is the first described chemokine that can exist either as a soluble protein or as a membrane-bound molecule. Both forms of fractalkine can mediate adhesion of cells expressing...
6.
Chensue S, Lukacs N, Yang T, Shang X, Frait K, Kunkel S, et al.
J Exp Med
. 2001 Mar;
193(5):573-84.
PMID: 11238588
Chemokine receptors transduce signals important for the function and trafficking of leukocytes. Recently, it has been shown that CC chemokine receptor (CCR)8 is selectively expressed by Th2 subsets, but its...
7.
Chen S, Mehrad B, Deng J, Vassileva G, Manfra D, Cook D, et al.
J Immunol
. 2001 Feb;
166(5):3362-8.
PMID: 11207292
Lungkine (CXCL15) is a novel CXC chemokine that is highly expressed in the adult mouse lung. To determine the biologic function of Lungkine, we generated Lungkine null mice by targeted...
8.
Manfra D, Chen S, Yang T, Sullivan L, Wiekowski M, Abbondanzo S, et al.
Am J Pathol
. 2001 Jan;
158(1):41-7.
PMID: 11141477
Transgenic mice expressing green fluorescent protein (GFP) were generated to provide a source of labeled leukocytes for cell transfer studies. The transgene comprises the GFP coding region under the transcriptional...
9.
Cook D, Prosser D, Forster R, Zhang J, KUKLIN N, Abbondanzo S, et al.
Immunity
. 2000 Jun;
12(5):495-503.
PMID: 10843382
Chemokine-directed migration of leukocyte subsets may contribute to the qualitative differences between systemic and mucosal immunity. Here, we demonstrate that in mice lacking the chemokine receptor CCR6, dendritic cells expressing...