Ryan M Lithgo
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Explore the profile of Ryan M Lithgo including associated specialties, affiliations and a list of published articles.
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7
Citations
34
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Recent Articles
1.
Aschenbrenner J, de Godoy A, Fairhead M, Tomlinson C, Winokan M, Balcomb B, et al.
bioRxiv
. 2024 Sep;
PMID: 39229067
Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for monthsor even years. Millions of people have been infected with CHIKV, mostly in low and...
2.
Lithgo R, Tomlinson C, Fairhead M, Winokan M, Thompson W, Wild C, et al.
bioRxiv
. 2024 May;
PMID: 38746446
are the causative agents of paediatric hand-foot-and-mouth disease, and a target for pandemic preparedness due to the risk of higher order complications in a large-scale outbreak. The 2A protease of...
3.
Ni X, Richardson R, Godoy A, de Godoy A, Ferla M, Kikawa C, et al.
bioRxiv
. 2024 May;
PMID: 38746305
The Zika viral protease NS2B-NS3 is essential for the cleavage of viral polyprotein precursor into individual structural and non-structural (NS) proteins and is therefore an attractive drug target. Generation of...
4.
Godoy A, Mesquita N, Noske G, Gawriljuk V, Lithgo R, Balcomb B, et al.
bioRxiv
. 2024 May;
PMID: 38746241
The Zika virus (ZIKV), discovered in Africa in 1947, swiftly spread across continents, causing significant concern due to its recent association with microcephaly in newborns and Guillain-Barré syndrome in adults....
5.
Calver J, Parmar N, Harris G, Lithgo R, Stylianou P, Zetterberg F, et al.
J Biol Chem
. 2024 Apr;
300(6):107300.
PMID: 38641066
Integrin-mediated activation of the profibrotic mediator transforming growth factor-β1 (TGF-β1), plays a critical role in idiopathic pulmonary fibrosis (IPF) pathogenesis. Galectin-3 is believed to contribute to the pathological wound healing...
6.
Boby M, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson M, et al.
Science
. 2023 Nov;
382(6671):eabo7201.
PMID: 37943932
We report the results of the COVID Moonshot, a fully open-science, crowdsourced, and structure-enabled drug discovery campaign targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease. We discovered...
7.
Lithgo R, Hanzevacki M, Harris G, Kamps J, Holden E, Gianga T, et al.
J Biol Chem
. 2023 Oct;
299(11):105331.
PMID: 37820867
The periplasmic chaperone SilF has been identified as part of an Ag(I) detoxification system in Gram-negative bacteria. Sil proteins also bind Cu(I) but with reported weaker affinity, therefore leading to...