Anu V Chandran
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Explore the profile of Anu V Chandran including associated specialties, affiliations and a list of published articles.
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13
Citations
81
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Recent Articles
1.
Chandran A, Alvarez D, Vanni S, Schnell J
Biochem J
. 2024 Sep;
481(20):1437-1448.
PMID: 39312180
The DP1 family of integral membrane proteins stabilize high membrane curvature in the endoplasmic reticulum and phagophores. Mutations in the human DP1 gene REEP1 are associated with Hereditary Spastic Paraplegia...
2.
Aschenbrenner J, de Godoy A, Fairhead M, Tomlinson C, Winokan M, Balcomb B, et al.
bioRxiv
. 2024 Sep;
PMID: 39229067
Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for monthsor even years. Millions of people have been infected with CHIKV, mostly in low and...
3.
Lithgo R, Tomlinson C, Fairhead M, Winokan M, Thompson W, Wild C, et al.
bioRxiv
. 2024 May;
PMID: 38746446
are the causative agents of paediatric hand-foot-and-mouth disease, and a target for pandemic preparedness due to the risk of higher order complications in a large-scale outbreak. The 2A protease of...
4.
Ni X, Richardson R, Godoy A, de Godoy A, Ferla M, Kikawa C, et al.
bioRxiv
. 2024 May;
PMID: 38746305
The Zika viral protease NS2B-NS3 is essential for the cleavage of viral polyprotein precursor into individual structural and non-structural (NS) proteins and is therefore an attractive drug target. Generation of...
5.
Godoy A, Mesquita N, Noske G, Gawriljuk V, Lithgo R, Balcomb B, et al.
bioRxiv
. 2024 May;
PMID: 38746241
The Zika virus (ZIKV), discovered in Africa in 1947, swiftly spread across continents, causing significant concern due to its recent association with microcephaly in newborns and Guillain-Barré syndrome in adults....
6.
Guay K, Ibba R, Kiappes J, Vasiljevic S, Boni F, De Benedictis M, et al.
iScience
. 2023 Oct;
26(10):107919.
PMID: 37822503
Misfolded glycoprotein recognition and endoplasmic reticulum (ER) retention are mediated by the ER glycoprotein folding quality control (ERQC) checkpoint enzyme, UDP-glucose glycoprotein glucosyltransferase (UGGT). UGGT modulation is a promising strategy...
7.
Brun J, Vasiljevic S, Gangadharan B, Hensen M, Chandran A, Hill M, et al.
ACS Cent Sci
. 2021 May;
7(4):586-593.
PMID: 34056088
Severe acute respiratory syndrome coronavirus 2 is the causative pathogen of the COVID-19 pandemic which as of March 29, 2021, has claimed 2 776 175 lives worldwide. Vaccine development efforts...
8.
Modenutti C, Blanco Capurro J, Ibba R, Alonzi D, Song M, Vasiljevic S, et al.
Structure
. 2020 Dec;
29(4):357-370.e9.
PMID: 33352114
UDP-glucose:glycoprotein glucosyltransferase (UGGT) flags misfolded glycoproteins for ER retention. We report crystal structures of full-length Chaetomium thermophilum UGGT (CtUGGT), two CtUGGT double-cysteine mutants, and its TRXL2 domain truncation (CtUGGT-ΔTRXL2). CtUGGT...
9.
Chandran A, Vijayan M
Biophys Rev
. 2017 May;
5(3):249-258.
PMID: 28510107
The action of RecA, an important eubacterial protein involved in recombination and repair, involves the transition from an inactive filament in the absence of DNA to an active filament formed...
10.
Chandran A, Jayanthi S, Vijayan M
J Biomol Struct Dyn
. 2017 Jan;
36(1):98-111.
PMID: 28049371
Eleven independent simulations, each involving three consecutive molecules in the RecA filament, carried out on the protein from Mycobacterium tuberculosis, Mycobacterium smegmatis and Escherichia coli and their Adenosine triphosphate (ATP)...