Max Winokan
Overview
Explore the profile of Max Winokan including associated specialties, affiliations and a list of published articles.
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9
Citations
14
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Recent Articles
1.
von Delft F, Ni X, Richardson R, Godoy A, Ferla M, Kikawa C, et al.
Res Sq
. 2025 Feb;
PMID: 39989958
The Zika viral protease NS2B-NS3 is essential for the cleavage of viral polyprotein precursor into individual structural and non-structural (NS) proteins and is therefore an attractive drug target. Generation of...
2.
Aschenbrenner J, de Godoy A, Fairhead M, Tomlinson C, Winokan M, Balcomb B, et al.
bioRxiv
. 2024 Sep;
PMID: 39229067
Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for monthsor even years. Millions of people have been infected with CHIKV, mostly in low and...
3.
Lee A, Amick I, Aschenbrenner J, Barr H, Benjamin J, Brandis A, et al.
bioRxiv
. 2024 Sep;
PMID: 39229055
A strategy for pandemic preparedness is the development of antivirals against a wide set of viral targets with complementary mechanisms of action. SARS-CoV-2 nsp3-mac1 is a viral macrodomain with ADP-ribosylhydrolase...
4.
Lithgo R, Tomlinson C, Fairhead M, Winokan M, Thompson W, Wild C, et al.
bioRxiv
. 2024 May;
PMID: 38746446
are the causative agents of paediatric hand-foot-and-mouth disease, and a target for pandemic preparedness due to the risk of higher order complications in a large-scale outbreak. The 2A protease of...
5.
Ni X, Richardson R, Godoy A, de Godoy A, Ferla M, Kikawa C, et al.
bioRxiv
. 2024 May;
PMID: 38746305
The Zika viral protease NS2B-NS3 is essential for the cleavage of viral polyprotein precursor into individual structural and non-structural (NS) proteins and is therefore an attractive drug target. Generation of...
6.
Godoy A, Mesquita N, Noske G, Gawriljuk V, Lithgo R, Balcomb B, et al.
bioRxiv
. 2024 May;
PMID: 38746241
The Zika virus (ZIKV), discovered in Africa in 1947, swiftly spread across continents, causing significant concern due to its recent association with microcephaly in newborns and Guillain-Barré syndrome in adults....
7.
Winokan M, Slocombe L, Al-Khalili J, Sacchi M
Sci Rep
. 2023 Dec;
13(1):21749.
PMID: 38065963
Proton transfer across hydrogen bonds in DNA can produce non-canonical nucleobase dimers and is a possible source of single-point mutations when these forms mismatch under replication. Previous computational studies have...
8.
King B, Winokan M, Stevenson P, Al-Khalili J, Slocombe L, Sacchi M
J Phys Chem B
. 2023 Mar;
127(19):4220-4228.
PMID: 36939840
The adenine-thymine tautomer (A*-T*) has previously been discounted as a spontaneous mutagenesis mechanism due to the energetic instability of the tautomeric configuration. We study the stability of A*-T* while the...
9.
Slocombe L, Winokan M, Al-Khalili J, Sacchi M
Commun Chem
. 2023 Jan;
5(1):144.
PMID: 36697962
Proton transfer between the DNA bases can lead to mutagenic Guanine-Cytosine tautomers. Over the past several decades, a heated debate has emerged over the biological impact of tautomeric forms. Here,...
10.
Slocombe L, Winokan M, Al-Khalili J, Sacchi M
J Phys Chem Lett
. 2022 Dec;
14(1):9-15.
PMID: 36562711
The misincorporation of a noncomplementary DNA base in the polymerase active site is a critical source of replication errors that can lead to genetic mutations. In this work, we model...