Ruwanthi N Gunawardane
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Explore the profile of Ruwanthi N Gunawardane including associated specialties, affiliations and a list of published articles.
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25
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965
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Recent Articles
1.
Chirikian O, Faynus M, Merk M, Singh Z, Muray C, Pham J, et al.
bioRxiv
. 2024 Jun;
PMID: 38895282
Hypertrophy Cardiomyopathy (HCM) is the most prevalent hereditary cardiovascular disease - affecting >1:500 individuals. Advanced forms of HCM clinically present with hypercontractility, hypertrophy and fibrosis. Several single-point mutations in b-myosin...
2.
Lee S, Roest A, Blair C, Kao K, Bremner S, Childers M, et al.
Proc Natl Acad Sci U S A
. 2024 Apr;
121(19):e2318413121.
PMID: 38683993
Determining the pathogenicity of hypertrophic cardiomyopathy-associated mutations in the β-myosin heavy chain () can be challenging due to its variable penetrance and clinical severity. This study investigates the early pathogenic...
3.
Gregor B, Coston M, Adams E, Arakaki J, Borensztejn A, Do T, et al.
Nat Protoc
. 2023 Dec;
19(2):565-594.
PMID: 38087082
To produce abundant cell culture samples to generate large, standardized image datasets of human induced pluripotent stem (hiPS) cells, we developed an automated workflow on a Hamilton STAR liquid handler...
4.
Lee S, Roest A, Blair C, Kao K, Bremner S, Childers M, et al.
bioRxiv
. 2023 Jun;
PMID: 37333118
Rationale: Over 200 mutations in the sarcomeric protein β-myosin heavy chain (MYH7) have been linked to hypertrophic cardiomyopathy (HCM). However, different mutations in MYH7 lead to variable penetrance and clinical...
5.
Viana M, Chen J, Knijnenburg T, Vasan R, Yan C, Arakaki J, et al.
Nature
. 2023 Jan;
613(7943):345-354.
PMID: 36599983
Understanding how a subset of expressed genes dictates cellular phenotype is a considerable challenge owing to the large numbers of molecules involved, their combinatorics and the plethora of cellular behaviours...
6.
Horwitz R, Riley E, Millan M, Gunawardane R
Nat Cell Biol
. 2021 Nov;
23(12):1213-1214.
PMID: 34845353
No abstract available.
7.
Grancharova T, Gerbin K, Rosenberg A, Roco C, Arakaki J, DeLizo C, et al.
Sci Rep
. 2021 Aug;
11(1):15845.
PMID: 34349150
We performed a comprehensive analysis of the transcriptional changes occurring during human induced pluripotent stem cell (hiPSC) differentiation to cardiomyocytes. Using single cell RNA-seq, we sequenced > 20,000 single cells...
8.
Gerbin K, Grancharova T, Donovan-Maiye R, Hendershott M, Anderson H, Brown J, et al.
Cell Syst
. 2021 May;
12(6):670-687.e10.
PMID: 34043964
Although some cell types may be defined anatomically or by physiological function, a rigorous definition of cell state remains elusive. Here, we develop a quantitative, imaging-based platform for the systematic...
9.
Roberts B, Hendershott M, Arakaki J, Gerbin K, Malik H, Nelson A, et al.
Stem Cell Reports
. 2019 Apr;
12(5):1145-1158.
PMID: 30956114
We describe a multistep method for endogenous tagging of transcriptionally silent genes in human induced pluripotent stem cells (hiPSCs). A monomeric EGFP (mEGFP) fusion tag and a constitutively expressed mCherry...
10.
Haupt A, Grancharova T, Arakaki J, Fuqua M, Roberts B, Gunawardane R
J Vis Exp
. 2018 Sep;
(138).
PMID: 30199041
A protocol is presented for generating human induced pluripotent stem cells (hiPSCs) that express endogenous proteins fused to in-frame N- or C-terminal fluorescent tags. The prokaryotic CRISPR/Cas9 system (clustered regularly...