Rune Toftgard
Overview
Explore the profile of Rune Toftgard including associated specialties, affiliations and a list of published articles.
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73
Citations
4638
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Recent Articles
1.
Bergstrom A, Gerling M, Van Hul N, Moro C, Rozell B, Toftgard R, et al.
Transgenic Res
. 2021 Jun;
30(5):701-707.
PMID: 34117597
Chronic cholestatic liver diseases including primary sclerosing cholangitis (PSC) present a complex spectrum with regards to the cause, age of manifestation and histopathological features. Current treatment options are severely limited...
2.
Norum J, Frings O, Kasper M, Bergholtz H, Zell Thime H, Bergstrom A, et al.
Int J Cancer
. 2019 Jun;
146(4):1125-1138.
PMID: 31219615
Increased expression of GLI1, the main Hedgehog signalling pathway effector, is related to unfavourable prognosis and progressive disease of certain breast cancer subtypes. We used conditional transgenic mice induced to...
3.
Hoelzl M, Heby-Henricson K, Gerling M, Dias J, Kuiper R, Trunkle C, et al.
Dev Biol
. 2017 Jul;
429(1):132-146.
PMID: 28688895
Suppressor of Fused (SUFU) is an essential negative regulator of the Hedgehog (HH) pathway and involved in GLI transcription factor regulation. Due to early embryonic lethality of Sufu mice, investigations...
4.
Blaas L, Pucci F, Messal H, Andersson A, Josue Ruiz E, Gerling M, et al.
Nat Cell Biol
. 2016 Nov;
18(12):1346-1356.
PMID: 27798604
The mammary gland is composed of a complex cellular hierarchy with unusual postnatal plasticity. The identities of stem/progenitor cell populations, as well as tumour-initiating cells that give rise to breast...
5.
Gerling M, Buller N, Kirn L, Joost S, Frings O, Englert B, et al.
Nat Commun
. 2016 Sep;
7:12936.
PMID: 27620212
No abstract available.
6.
Gerling M, Buller N, Kirn L, Joost S, Frings O, Englert B, et al.
Nat Commun
. 2016 Aug;
7:12321.
PMID: 27492255
A role for Hedgehog (Hh) signalling in the development of colorectal cancer (CRC) has been proposed. In CRC and other solid tumours, Hh ligands are upregulated; however, a specific Hh...
7.
Kasper M, Toftgard R, Jaks V
Methods Mol Biol
. 2016 Jul;
1453:123-36.
PMID: 27431252
During the past decade, the rapid development of new transgenic and knock-in mouse models has propelled epidermal stem-cell research into "fast-forward mode". It has become possible to identify and visualize...
8.
Raducu M, Fung E, Serres S, Infante P, Barberis A, Fischer R, et al.
EMBO J
. 2016 May;
35(13):1400-16.
PMID: 27234298
Skp1-Cul1-F-box protein (SCF) ubiquitin ligases direct cell survival decisions by controlling protein ubiquitylation and degradation. Sufu (Suppressor of fused) is a central regulator of Hh (Hedgehog) signaling and acts as...
9.
Bosma M, Gerling M, Pasto J, Georgiadi A, Graham E, Shilkova O, et al.
Nat Commun
. 2016 Apr;
7:11314.
PMID: 27066907
FNDC4 is a secreted factor sharing high homology with the exercise-associated myokine irisin (FNDC5). Here we report that Fndc4 is robustly upregulated in several mouse models of inflammation as well...
10.
Fullgrabe A, Joost S, Are A, Jacob T, Sivan U, Haegebarth A, et al.
Stem Cell Reports
. 2015 Nov;
5(5):843-855.
PMID: 26607954
The dynamics and interactions between stem cell pools in the hair follicle (HF), sebaceous gland (SG), and interfollicular epidermis (IFE) of murine skin are still poorly understood. In this study,...