Stephan Teglund
Overview
Explore the profile of Stephan Teglund including associated specialties, affiliations and a list of published articles.
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11
Citations
786
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Recent Articles
1.
Hoelzl M, Heby-Henricson K, Gerling M, Dias J, Kuiper R, Trunkle C, et al.
Dev Biol
. 2017 Jul;
429(1):132-146.
PMID: 28688895
Suppressor of Fused (SUFU) is an essential negative regulator of the Hedgehog (HH) pathway and involved in GLI transcription factor regulation. Due to early embryonic lethality of Sufu mice, investigations...
2.
Hoelzl M, Heby-Henricson K, Bilousova G, Rozell B, Kuiper R, Kasper M, et al.
Stem Cells Dev
. 2015 Jul;
24(21):2547-60.
PMID: 26176320
The hedgehog (Hh) signaling pathway plays fundamental roles during embryonic development and tumorigenesis. Previously, we have shown that ablation of the tumor suppressor and negative regulator, Suppressor of fused (Sufu),...
3.
Heby-Henricson K, Bergstrom A, Rozell B, Toftgard R, Teglund S
Mol Carcinog
. 2011 Sep;
51(9):754-60.
PMID: 21882258
Basal cell carcinoma of the skin typically carries genetic alterations in components of the hedgehog (HH) signaling pathway. Previously, we generated a knockout mouse with a loss-of-function mutation in suppressor...
4.
Kasper M, Jaks V, Are A, Bergstrom A, Schwager A, Svard J, et al.
Proc Natl Acad Sci U S A
. 2011 Feb;
108(10):4099-104.
PMID: 21321199
Chronic wounds and acute trauma constitute well-established risk factors for development of epithelial-derived skin tumors, although the underlying mechanisms are largely unknown. Basal cell carcinomas (BCCs) are the most common...
5.
Palaniswamy R, Teglund S, Lauth M, Zaphiropoulos P, Shimokawa T
BMC Mol Biol
. 2010 May;
11:32.
PMID: 20433698
Background: Alternative splicing is one of the key mechanisms that generate biological diversity. Even though alternative splicing also occurs in the 5' and 3' untranslated regions (UTRs) of mRNAs, the...
6.
Teglund S, Toftgard R
Biochim Biophys Acta
. 2010 Jan;
1805(2):181-208.
PMID: 20085802
The Hedgehog (Hh) signaling pathway is of central importance during embryo development in metazoans and governs a diverse array of processes including cell proliferation, differentiation, and tissue patterning. In normal...
7.
Kise Y, Morinaka A, Teglund S, Miki H
Biochem Biophys Res Commun
. 2009 Jul;
387(3):569-74.
PMID: 19622347
Hedgehog (Hh) signaling activates the transcription factor Gli by suppressing the function of the suppressor of fused (Sufu) protein in mammals. Here, a novel role of mammalian Sufu is identified...
8.
Jia J, Kolterud A, Zeng H, Hoover A, Teglund S, Toftgard R, et al.
Dev Biol
. 2009 Apr;
330(2):452-60.
PMID: 19371734
The Hedgehog (Hh) family of secreted proteins regulates mammalian development and cancer formation through Gli transcription factors, which exist in both activator and repressor forms. In vertebrates, the primary cilia...
9.
Svard J, Rozell B, Toftgard R, Teglund S
Mol Carcinog
. 2008 Sep;
48(5):408-19.
PMID: 18781608
Dysregulation of the Hedgehog signaling pathway is central to the development of certain tumor types, including medulloblastoma and basal cell carcinoma (BCC). Patched1 (Ptch1) and Suppressor of fused (Sufu) are...
10.
Svard J, Heby-Henricson K, Henricson K, Persson-Lek M, Rozell B, Lauth M, et al.
Dev Cell
. 2006 Feb;
10(2):187-97.
PMID: 16459298
The Hedgehog (Hh) pathway plays important roles during embryogenesis and carcinogenesis. Here, we show that ablation of the mouse Suppressor of fused (Sufu), an intracellular pathway component, leads to embryonic...