Rudolf Waelchli
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Explore the profile of Rudolf Waelchli including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
110
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Recent Articles
1.
Thoma G, Miltz W, Waelchli R, Orain D, Spanka C, Decoret O, et al.
J Med Chem
. 2025 Feb;
68(4):4721-4742.
PMID: 39960261
Leukotriene C4 synthase (LTC4S) is a glutathione -transferase that mediates the biosynthesis of cysteinyl leukotriene C4 (LTC4). Cysteinyl leukotrienes (CysLTs) are lipid mediators that drive type 2 inflammation, bronchoconstriction, and...
2.
Thoma G, Duthaler R, Waelchli R, Hauchard A, Bruno S, Strittmatter-Keller U, et al.
J Med Chem
. 2023 Jan;
66(3):2161-2168.
PMID: 36657024
The JAK kinases JAK1, JAK2, JAK3, and TYK2 play key roles in cytokine signaling. Activation of the JAK/STAT pathways is linked to many diseases involving the immune system, including atopic...
3.
Pulz R, Angst D, Dawson J, Gessier F, Gutmann S, Hersperger R, et al.
ACS Med Chem Lett
. 2019 Oct;
10(10):1467-1472.
PMID: 31620235
Bruton's tyrosine kinase (BTK) is a member of the TEC kinase family and is selectively expressed in a subset of immune cells. It is a key regulator of antigen receptor...
4.
Schlapbach A, Feifel R, Hawtin S, Heng R, Koch G, Moebitz H, et al.
Bioorg Med Chem Lett
. 2008 Oct;
18(23):6142-6.
PMID: 18945615
Pyrrolo-pyrimidones of the general structure 1 were synthesized and evaluated for their potential as MK2 inhibitors. Potent derivatives were discovered which inhibit MK2 in the nanomolar range and show potent...
5.
Waelchli R, Bollbuck B, Bruns C, Buhl T, Eder J, Feifel R, et al.
Bioorg Med Chem Lett
. 2005 Oct;
16(1):108-12.
PMID: 16236504
The design, synthesis, and the biological evaluation of 2-benzamido-pyrimidines as novel IKK inhibitors are described. By optimization of the lead compound 3, compounds 16 and 24 are identified as good...
6.
Revesz L, Bollbuck B, Buhl T, Eder J, Esser R, Feifel R, et al.
Bioorg Med Chem Lett
. 2005 Oct;
15(23):5160-4.
PMID: 16198561
Cinnamides as novel CCR1 antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse collagen induced arthritis.