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Design and Preparation of 2-benzamido-pyrimidines As Inhibitors of IKK

Overview
Specialty Biochemistry
Date 2005 Oct 21
PMID 16236504
Citations 80
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Abstract

The design, synthesis, and the biological evaluation of 2-benzamido-pyrimidines as novel IKK inhibitors are described. By optimization of the lead compound 3, compounds 16 and 24 are identified as good inhibitors of IKK2 with IC(50) values of 40 and 25 nM, respectively. Compound 16 also demonstrated significant in vivo activity in an acute model of cytokine release.

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