Novel CCR1 Antagonists with Oral Activity in the Mouse Collagen Induced Arthritis

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2005 Oct 4

PMID 16198561

Citations 5

Authors

Laszlo Revesz

Birgit Bollbuck

Thomas Buhl

Joerg Eder

Ronald Esser

Roland Feifel

Richard Heng

Peter Hiestand

Benedicte Jachez-Demange

Pius Loetscher

Helmut Sparrer

Achim Schlapbach

Rudolf Waelchli

Affiliations

Soon will be listed here.

Abstract

Cinnamides as novel CCR1 antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse collagen induced arthritis.

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