Achim Schlapbach
Overview
Explore the profile of Achim Schlapbach including associated specialties, affiliations and a list of published articles.
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Articles
25
Citations
391
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Recent Articles
1.
Velcicky J, Ngo E, Bauer M, Meyer A, Schlapbach A, Racine S, et al.
ChemMedChem
. 2024 Dec;
e202400851.
PMID: 39715021
The pro-inflammatory cytokine interleukin-17A (IL-17) plays an important role in the body's defense against bacterial and fungal infections. However, overexpression of IL-17 has been associated with several diseases, including rheumatoid...
2.
Velcicky J, Bauer M, Schlapbach A, Lapointe G, Meyer A, Vogtle M, et al.
J Med Chem
. 2024 Sep;
67(18):16692-16711.
PMID: 39276085
IL-17, a pro-inflammatory cytokine produced mainly by Th17 cells, is involved in the immune response to fungal and bacterial infections, whereas its aberrant production is associated with autoimmune and inflammatory...
3.
Unterreiner A, Rubert J, Kauffmann M, Fruhauf A, Heiser D, Erbel P, et al.
Biochem Biophys Res Commun
. 2021 Feb;
545:177-182.
PMID: 33561652
The NLRP3 inflammasome is a critical component of the innate immune response to sterile inflammation. Its regulation involves a priming step, required for up-regulation of inflammasome protagonists and an activation...
4.
Soldermann C, Simic O, Renatus M, Erbel P, Melkko S, Wartmann M, et al.
J Med Chem
. 2020 Nov;
63(23):14576-14593.
PMID: 33252239
MALT1 plays a central role in immune cell activation by transducing NF-κB signaling, and its proteolytic activity represents a key node for therapeutic intervention. Two cycles of scaffold morphing of...
5.
Quancard J, Simic O, Soldermann C, Aichholz R, Blatter M, Renatus M, et al.
J Med Chem
. 2020 Nov;
63(23):14594-14608.
PMID: 33216547
The paracaspase MALT1 has gained increasing interest as a target for the treatment of subsets of lymphomas as well as autoimmune diseases, and there is a need for suitable compounds...
6.
Velcicky J, Wilcken R, Cotesta S, Janser P, Schlapbach A, Wagner T, et al.
J Med Chem
. 2020 Aug;
63(17):9856-9875.
PMID: 32856916
G-protein-coupled receptor SUCNR1 (succinate receptor 1 or GPR91) senses the citric cycle intermediate succinate and is implicated in various pathological conditions such as rheumatoid arthritis, liver fibrosis, or obesity. Here,...
7.
Martin K, Junker U, Tritto E, Sutter E, Rubic-Schneider T, Morgan H, et al.
Front Immunol
. 2020 May;
11:745.
PMID: 32425939
Genetic disruption or short-term pharmacological inhibition of MALT1 protease is effective in several preclinical models of autoimmunity and B cell malignancies. Despite these protective effects, the severe reduction in regulatory...
8.
Martin K, Touil R, Cvijetic G, Israel L, Kolb Y, Sarret S, et al.
Arthritis Rheumatol
. 2020 Jan;
72(6):919-930.
PMID: 31943941
Objective: Fcγ receptors (FcγR) play important roles in both protective and pathogenic immune responses. The assembly of the CBM signalosome encompassing caspase recruitment domain-containing protein 9, B cell CLL/lymphoma 10,...
9.
Kallen J, Izaac A, Chau S, Wirth E, Schoepfer J, Mah R, et al.
ChemMedChem
. 2019 May;
14(14):1305-1314.
PMID: 31066983
Hdm2 (human MDM2, human double minute 2 homologue) counteracts p53 function by direct binding to p53 and by ubiquitin-dependent p53 protein degradation. Activation of p53 by inhibitors of the p53-Hdm2...
10.
Quancard J, Klein T, Fung S, Renatus M, Hughes N, Israel L, et al.
Nat Chem Biol
. 2019 Jan;
15(3):304-313.
PMID: 30692685
MALT1 paracaspase is central for lymphocyte antigen-dependent responses including NF-κB activation. We discovered nanomolar, selective allosteric inhibitors of MALT1 that bind by displacing the side chain of Trp580, locking the...