Rudolf Grosschedl
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Explore the profile of Rudolf Grosschedl including associated specialties, affiliations and a list of published articles.
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86
Citations
4719
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Recent Articles
11.
Qiu Z, Guo W, Dong B, Wang Y, Deng P, Wang C, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(28):e2119518119.
PMID: 35867755
Early B cell factor 1 (EBF1) is a transcriptional factor with a variety of roles in cell differentiation and metabolism. However, the functional roles of EBF1 in tumorigenesis remain elusive....
12.
Roy R, Ramamoorthy S, Shapiro B, Kaileh M, Hernandez D, Sarantopoulou D, et al.
Immunity
. 2022 Jun;
55(6):1135.
PMID: 35704994
No abstract available.
13.
Bayer M, Grosschedl R
Mol Cell
. 2022 Mar;
82(5):884-886.
PMID: 35245453
Gain-of-function NOTCH1 mutations drive oncogenic MYC expression in T-ALL cells. Zhou et al. (2022) reveal that Notch-targeted therapy-resistant T-ALL cells activate EBF1, which promotes a T-to-B lineage shift and maintains...
14.
Roy R, Ramamoorthy S, Shapiro B, Kaileh M, Hernandez D, Sarantopoulou D, et al.
Immunity
. 2021 Oct;
54(11):2465-2480.e5.
PMID: 34706222
Epigenetic reprogramming underlies specification of immune cell lineages, but patterns that uniquely define immune cell types and the mechanisms by which they are established remain unclear. Here, we identified lineage-specific...
15.
Antonio Urrutia G, Ramachandran H, Cauchy P, Boo K, Ramamoorthy S, Boller S, et al.
Genes Dev
. 2021 Jul;
35(15-16):1142-1160.
PMID: 34244292
The establishment of cell fates involves alterations of transcription factor repertoires and repurposing of transcription factors by post-translational modifications. In embryonic stem cells (ESCs), the chromatin organizers SATB2 and SATB1...
16.
Bischof O, Schwamborn K, Martin N, Werner A, Sustmann C, Grosschedl R, et al.
Mol Cell
. 2020 Dec;
80(6):1140.
PMID: 33338405
No abstract available.
17.
Kapoor T, Corrado M, Pearce E, Pearce E, Grosschedl R
Sci Rep
. 2020 Dec;
10(1):21626.
PMID: 33318509
MZB1 is an endoplasmic reticulum (ER)-resident protein that plays an important role in the humoral immune response by enhancing the interaction of the μ immunoglobulin (Ig) heavy chain with the...
18.
Wang Y, Zolotarev N, Yang C, Rambold A, Mittler G, Grosschedl R
Immunity
. 2020 Nov;
53(6):1151-1167.e6.
PMID: 33159853
Establishment of B-lineage-specific gene expression requires the binding of transcription factors to inaccessible chromatin of progenitors. The transcription factor EBF1 can bind genomic regions prior to the detection of chromatin...
19.
Kucinski I, Wilson N, Hannah R, Kinston S, Cauchy P, Lenaerts A, et al.
EMBO J
. 2020 Oct;
39(24):e104983.
PMID: 33103827
Recent advances in molecular profiling provide descriptive datasets of complex differentiation landscapes including the haematopoietic system, but the molecular mechanisms defining progenitor states and lineage choice remain ill-defined. Here, we...
20.
Ramamoorthy S, Kometani K, Herman J, Bayer M, Boller S, Edwards-Hicks J, et al.
Genes Dev
. 2020 Oct;
34(21-22):1503-1519.
PMID: 33004416
and mutations are associated with the development of B progenitor acute lymphoblastic leukemia (B-ALL) in humans. To understand the molecular networks driving leukemia in the (dHet) mouse model for B-ALL,...